Trial reportJournal of veterinary internal medicine
Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs.
Trial report in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Short versus longer duration antibiotic treatment for urinary tract infections in companion animals: a systematic review and meta-analysis.BMC veterinary research · 2025Pooled it
- Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole treatment in female dogs with uncomplicated bacterial cystitis.Journal of veterinary internal medicineTrial
- Understanding veterinarians' antibiotic choices and eliciting acceptable non-inferiority margins for randomized trials: a multi-country study.JAC-antimicrobial resistance · 2026Article
- A Review of Fluoroquinolones with a Focus on Veterinary-Approved Agents.Biomolecules · 2026Review
- Not just another "AMR is important" message yet again… How veterinarians are making clear progress on better use of antimicrobials.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- A double-blinded randomized placebo-controlled non-inferiority trial protocol for postoperative infections associated with canine pyometra.BMC veterinary research · 2023Article
- Antimicrobial Resistance Profile of Bacterial Isolates from Urinary Tract Infections in Companion Animals in Central Italy.Antibiotics (Basel, Switzerland) · 2022Article
- Enrofloxacin-The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?International journal of molecular sciences · 2022Review
- Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra.Journal of veterinary internal medicine · 2022Article
- Results of urinary bacterial cultures and antibiotic susceptibility testing of dogs and cats in the UK.The Journal of small animal practice · 2021Article
- In Vitro Killing of Canine Urinary Tract Infection Pathogens by Ampicillin, Cephalexin, Marbofloxacin, Pradofloxacin, and Trimethoprim/Sulfamethoxazole.Microorganisms · 2021Article
- Evaluation of antimicrobial prescriptions in dogs with suspected bacterial urinary tract disease.Journal of veterinary internal medicine · 2021Article
- Tracing Mastitis Pathogens-Epidemiological Investigations of aAnimals : an open access journal from MDPI · 2021Article
- Use of Local Antibiogram Data and Antimicrobial Importance Ratings to Select Optimal Empirical Therapies for Urinary Tract Infections in Dogs and Cats.Antibiotics (Basel, Switzerland) · 2020Article
- Urinary tract infection and subclinical bacteriuria in cats: A clinical update.Journal of feline medicine and surgery · 2019Review
- Evaluation of the Live Biotherapeutic Product, Asymptomatic Bacteriuria Escherichia coli 2-12, in Healthy Dogs and Dogs with Clinical Recurrent UTI.Journal of veterinary internal medicine · 2018Article
- Outcomes in dogs with uncomplicated, presumptive bacterial pneumonia treated with short or long course antibiotics.The Canadian veterinary journal = La revue veterinaire canadienne · 2017Article
- UropathogenicBioMed research international · 2017Article
- Prospective study evaluating the incidence of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing chemotherapy.Veterinary medicine and science · 2016Article
- Urinary tract infections: treatment/comparative therapeutics.The Veterinary clinics of North America. Small animal practice · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncomplicated urinary tract infections (UTI) in dogs usually are treated with antimicrobial drugs for 10-14 days. Shorter duration antimicrobial regimens have been evaluated in human patients. HYPOTHESIS: A high dose short duration (HDSD) enrofloxacin protocol administered to dogs with uncomplicated UTI will not be inferior to a 14-day treatment regimen with amoxicillin-clavulanic acid. ANIMALS: Client-owned adult, otherwise healthy dogs with aerobic bacterial urine culture yielding ≥ 10(3) CFU/mL of bacteria after cystocentesis.
methodsProspective, multicenter, controlled, randomized blinded clinical trial. Enrolled dogs were randomized to group 1 (enrofloxacin 18-20 mg/kg PO q24h for 3 days) or group 2 (amoxicillin-clavulanic acid 13.75-25 mg/kg PO q12h for 14 days). Urine cultures were obtained at days 0, 10, and 21. Microbiologic and clinical cure rates were evaluated 7 days after antimicrobial treatment was discontinued. Lower urinary tract signs and adverse events also were recorded.
resultsThere were 35 dogs in group 1 and 33 in group 2. The microbiologic cure rate was 77.1 and 81.2% for groups 1 and 2, respectively. The clinical cure rate was 88.6 and 87.9% for groups 1 and 2, respectively. Cure rates between groups did not differ according to the selected margin of noninferiority. CONCLUSIONS AND CLINICAL IMPORTANCE: HDSD enrofloxacin treatment was not inferior to a conventional amoxicillin-clavulanic acid protocol for the treatment of uncomplicated bacterial UTI in dogs. Further research is warranted to determine if this protocol will positively impact owner compliance and decrease the emergence of antimicrobial resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.