ArticleMolecular microbiology2012
Cactin is essential for G1 progression in Toxoplasma gondii.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 2 citations in OpenAlex.
- OsCactin positively regulates the drought stress response in rice.Plant cell reports · 2024Article
- Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver.Nature communications · 2024Article
- Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm.Current opinion in microbiology · 2023Review
- Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.PLoS biology · 2022Article
- Toxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle.mSphere · 2020Article
- ApiAP2 Transcription Factors in Apicomplexan Parasites.Pathogens (Basel, Switzerland) · 2019Review
- Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New.Trends in parasitology · 2018Review
- Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii.BMC genomics · 2017Article
- Checkpoints of apicomplexan cell division identified in Toxoplasma gondii.PLoS pathogens · 2017Article
- TmCactin plays an important role in Gram-negative and -positive bacterial infection by regulating expression of 7 AMP genes in Tenebrio molitor.Scientific reports · 2017Article
- Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.Molecular microbiology · 2017Article
- Sexual development in Plasmodium parasites: knowing when it's time to commit.Nature reviews. Microbiology · 2015Review
- A novel bipartite centrosome coordinates the apicomplexan cell cycle.PLoS biology · 2015Article
- Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.The EMBO journal · 2015Article
- Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2014Article
- CACN-1/Cactin plays a role in Wnt signaling in C. elegans.PloS one · 2014Article
- The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant.Journal of cell science · 2013Article
- Genetic manipulation in Δku80 strains for functional genomic analysis of Toxoplasma gondii.Journal of visualized experiments : JoVE · 2013Article
- Discovery of a splicing regulator required for cell cycle progression.PLoS genetics · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before the middle of the G1 stage of the tachyzoite cell cycle. This arrest is caused by a point mutation in a gene conserved across eukaryotes, Cactin, whose product localizes to the nucleus. To elucidate the role of TgCactin we performed genome-wide expression profiling. Besides the expected G1 expression profile, many genes associated with the extracellular state as well as with the bradyzoite cyst stage were identified. Consistent with these profiles were the expression of AP2 transcription factors typically associated with extracellular and bradyzoite stage parasites. This suggests a role for TgCactin in control of gene expression. As TgCactin does not contain any functionally defined domains we reasoned TgCactin exerts its function through interactions with other proteins. In support of this model we demonstrated that TgCactin is present in a protein complex and can oligomerize. Taken together, these results suggest that TgCactin acts as a pivotal protein potentially regulating gene expression at several transition points in parasite development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.