ArticleBritish journal of clinical pharmacology2012
Dose-response relationship between selective serotonin re-uptake inhibitors and injurious falls: a study in nursing home residents with dementia.
Article in British journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Effect of selective serotonin reuptake inhibitors in Alzheimer's disease with comorbid depression: a meta-analysis of depression and cognitive outcomes.Drugs & aging · 2012Pooled it
- Cost-utility of medication withdrawal in older fallers: results from the improving medication prescribing to reduce risk of FALLs (IMPROveFALL) trial.BMC geriatrics · 2016Trial
- Trial
- Longitudinal patterns of antidepressant and benzodiazepine use associated with injurious falls in older adults with depression: a retrospective cohort study.BMC medicine · 2025Article
- Time-Varying Hazard of Patient Falls in Hospital: A Retrospective Case-Control Study.Healthcare (Basel, Switzerland) · 2023Article
- Antihypertensive medication in frail older adults: A narrative review through a deprescribing lens.American heart journal plus : cardiology research and practice · 2022Article
- Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults.PloS one · 2022Article
- Risk of Fractures in Older Adults with Chronic Non-cancer Pain Receiving Concurrent Benzodiazepines and Opioids: A Nested Case-Control Study.Drugs & aging · 2021Article
- Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy.Deutsches Arzteblatt international · 2019Review
- Fall-risk-increasing adverse reactions-is there value in easily accessible drug information? A case-control study.European journal of clinical pharmacology · 2019Article
- The Association Between Central Nervous System-Active Medication Use and Fall-Related Injury in Community-Dwelling Older Adults with Dementia.Pharmacotherapy · 2019Article
- The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Psychotropic Medication Use among Medicare Beneficiaries Following Traumatic Brain Injury.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- A Review of Adverse Outcomes Associated with Psychoactive Drug Use in Nursing Home Residents with Dementia.Drugs & aging · 2016Review
- Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?Current osteoporosis reports · 2016Review
- Pharmacologic treatment of depression in the elderly.Canadian family physician Medecin de famille canadien · 2014Review
- Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients.Therapeutics and clinical risk management · 2014Review
- Depression in cognitive impairment.Current psychiatry reports · 2013Review
- Potentially inappropriate medications in a large cohort of patients in geriatric units: association with clinical and functional characteristics.European journal of clinical pharmacology · 2013Article
- Editors' pick 2012.British journal of clinical pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe contribution of selective serotonin re-uptake inhibitors (SSRIs) to injurious fall risk in patients with dementia has not been quantified precisely until now. Our objective was to determine whether a dose-response relationship exists for the use of SSRIs and injurious falls in a population of nursing home residents with dementia.
methodsDaily drug use and daily falls were recorded in 248 nursing home residents with dementia from 1 January 2006 until 1 January 2008. For each resident and for each day of the study period, data on drug use were abstracted from the prescription database, and information on falls and subsequent injuries was retrieved from a standardized incident report system, resulting in a dataset of 85,074 person-days.
resultsWe found a significant dose-response relationship between injurious falls and the use of SSRIs. The risk of an injurious fall increased significantly with 31% at 0.25 of the Defined Daily Dose (DDD) of a SSRI, 73% at 0.50 DDD, and 198% at 1.00 DDD (Hazard ratio = 2.98; 95% confidence interval 1.94, 4.57). The risk increased further in combination with a hypnotic or sedative.
conclusionsEven at low doses, SSRIs are associated with increased risk of an injurious fall in nursing home residents with dementia. Higher doses increase the risk further with a three-fold risk at 1.00 DDD. New treatment protocols might be needed that take into account the dose-response relationship between SSRIs and injurious falls.
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