ArticlePloS one2012
In vitro studies on erythrosine-based photodynamic therapy of malignant and pre-malignant oral epithelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
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- In Vitro Exploration of Dark Cytotoxicity of Anthocyanin-Curcumin Combination, A Herbal Photosensitizer.Cureus · 2024Article
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- The water soluble axially disubstituted silicon phthalocyanines: photophysicochemical properties and in vitro studies.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes.PloS one · 2017Article
- The effect of aloe emodin-encapsulated nanoliposome-mediated r-caspase-3 gene transfection and photodynamic therapy on human gastric cancer cells.Cancer medicine · 2016Article
- T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2015Article
- Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines.Frontiers in immunology · 2015Review
- Danger signalling during cancer cell death: origins, plasticity and regulation.Cell death and differentiation · 2014Review
- Comparison of light-emitting diode wavelength on activity and migration of rabbit ACL cells.Lasers in medical science · 2014Article
- Photodynamic therapy: occupational hazards and preventative recommendations for clinical administration by healthcare providers.Photomedicine and laser surgery · 2013Review
- Immunogenic cell death and DAMPs in cancer therapy.Nature reviews. Cancer · 2012Review
- Effect of preirradiation time of erythrosine + potassium iodide-mediated photodynamic therapy on candidal inhibition and singlet oxygen formation.Photochemistry and photobiologyArticle
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- Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic Therapy (PDT) involves the administration of a tumor localizing photosensitizing agent, which upon activation with light of an appropriate wavelength leads to the destruction of the tumor cells. The aim of the present study was to determine the efficacy of erythrosine as a photosensitizer for the PDT of oral malignancies. The drug uptake kinetics of erythrosine in malignant (H357) and pre-malignant (DOK) oral epithelial cells and their susceptibility to erythrosine-based PDT was studied along with the determination of the subcellular localization of erythrosine. This was followed by initial investigations into the mechanism of cell killing induced following PDT involving both high and low concentrations of erythrosine. The results showed that at 37 °C the uptake of erythrosine by both DOK and H357 cells increased in an erythrosine dose dependent manner. However, the percentage of cell killing observed following PDT differed between the 2 cell lines; a maximum of ~80% of DOK cell killing was achieved as compared to ~60% killing for H357 cells. Both the DOK and H357 cell types exhibited predominantly mitochondrial accumulation of erythrosine, but the mitochondrial trans-membrane potential (ΔΨ(m)) studies showed that the H357 cells were far more resistant to the changes in ΔΨ(m) when compared to the DOK cells and this might be a factor in the apparent relative resistance of the H357 cells to PDT. Finally, cell death morphology and caspase activity analysis studies demonstrated the occurrence of extensive necrosis with high dose PDT in DOK cells, whereas apoptosis was observed at lower doses of PDT for both cell lines. For H357 cells, high dose PDT produced both apoptotic as well as necrotic responses. This is the first instance of erythrosine-based PDT's usage for cancer cell killing.
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