ArticlePloS one2012
Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 250 citations in OpenAlex.
- Wound healing in Atlantic spiny dogfish sharks.Scientific reports · 2026Article
- Loss of tissue-state plasticity: a conceptual framework for age-associated regenerative failure.Inflammation and regeneration · 2026Review
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.The Journal of clinical investigation · 2026Article
- Article
- Macrophages orchestrate tail regeneration in lizardsFrontiers in cell and developmental biology · 2026Article
- RestoringFrontiers in cell and developmental biology · 2026Article
- Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing.Materials today. Bio · 2025Article
- Colostrum-Derived Exosomal Lactoferrin Promotes Skin Fibroblast Regeneration by Suppressing Inflammatory Responses.Current issues in molecular biology · 2025Article
- Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration.Nature communications · 2025Article
- Keratinocyte-driven dermal collagen formation in the axolotl skin.Nature communications · 2025Article
- Systemic factors associated with antler growth promote complete wound healing.NPJ Regenerative medicine · 2025Article
- The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds.Frontiers in immunology · 2025Article
- Antibacterial Activity of AXOTL-13, a Novel Peptide Identified from the Transcriptome of the SalamanderPharmaceutics · 2024Article
- Nature's Secret Neuro-Regeneration Pathway in Axolotls, Polychaetes and Planarians for Human Therapeutic Target Pathways.International journal of molecular sciences · 2024Review
- Granulocyte colony stimulating factor promotes scarless tissue regeneration.Cell reports · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- Review
- UV radiation-induced peptides in frog skin confer protection against cutaneous photodamage through suppressing MAPK signaling.MedComm · 2024Article
- Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.Developmental biology · 2024Review
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
While considerable progress has been made towards understanding the complex processes and pathways that regulate human wound healing, regenerative medicine has been unable to develop therapies that coax the natural wound environment to heal scar-free. The inability to induce perfect skin regeneration stems partly from our limited understanding of how scar-free healing occurs in a natural setting. Here we have investigated the wound repair process in adult axolotls and demonstrate that they are capable of perfectly repairing full thickness excisional wounds made on the flank. In the context of mammalian wound repair, our findings reveal a substantial reduction in hemostasis, reduced neutrophil infiltration and a relatively long delay in production of new extracellular matrix (ECM) during scar-free healing. Additionally, we test the hypothesis that metamorphosis leads to scarring and instead show that terrestrial axolotls also heal scar-free, albeit at a slower rate. Analysis of newly forming dermal ECM suggests that low levels of fibronectin and high levels of tenascin-C promote regeneration in lieu of scarring. Lastly, a genetic analysis during wound healing comparing epidermis between aquatic and terrestrial axolotls suggests that matrix metalloproteinases may regulate the fibrotic response. Our findings outline a blueprint to understand the cellular and molecular mechanisms coordinating scar-free healing that will be useful towards elucidating new regenerative therapies targeting fibrosis and wound repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.