ArticleFrontiers in psychiatry2012
A Peephole into the Brain: Neuropathological Features of Alzheimer's Disease Revealed by in vivo Two-Photon Imaging.
Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice.International journal of molecular sciences · 2024Review
- Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Light on Alzheimer's disease: from basic insights to preclinical studies.Frontiers in aging neuroscience · 2024Review
- Amyloid pathology impairs experience-dependent inhibitory synaptic plasticity.bioRxiv : the preprint server for biology · 2023Article
- Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice.Communications biology · 2021Article
- Femtosecond diode-based time lens laser for multiphoton microscopy.Biomedical optics express · 2021Article
- Micromotor-based localized electroporation and gene transfection of mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- From Light to Sound: Photoacoustic and Ultrasound Imaging in Fundamental Research of Alzheimer's Disease.OBM neurobiology · 2020Article
- Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy.Science advances · 2018Article
- Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging.EBioMedicine · 2018Article
- The Role of Glial Cells and Synapse Loss in Mouse Models of Alzheimer's Disease.Frontiers in cellular neuroscience · 2018Review
- Virus-based nanoparticles as platform technologies for modern vaccines.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques.Journal of visualized experiments : JoVE · 2016Article
- Relationship between total phenolic contents and biological properties of propolis from 20 different regions in South Korea.BMC complementary and alternative medicine · 2016Article
- Microglia as a critical player in both developmental and late-life CNS pathologies.Acta neuropathologica · 2014Review
- Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.Molecular psychiatry · 2014Article
- In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.Acta neuropathologica communications · 2014Article
- Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease.Acta neuropathologica · 2013Article
- Contributions of microglia to structural synaptic plasticity.Journal of experimental neuroscience · 2013Review
- Amyloid plaque formation precedes dendritic spine loss.Acta neuropathologica · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a protein conformational disorder characterized by two major neuropathological features: extracellular accumulations of amyloid-β peptides in the form of plaques and intracellular tangles, consisting of hyperphosphorylated tau proteins. Several morphological and functional changes are associated with these lesions in the diseased brain, such as dendritic and synaptic alterations, as well as microglial and astroglial recruitment and their activation. The availability of transgenic mouse models that mimic key aspects of the disease in conjunction with recent advances in two-photon imaging facilitate the study of fundamental aspects of AD pathogenesis and allow for longitudinally monitoring the efficacy of therapeutic interventions. Here, we review the ambitious efforts to understand the relationship between the main neuropathological hallmarks of AD and their associated structural and functional abnormalities by means of in vivo two-photon imaging.
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