ReviewPharmacology & therapeutics2012
Estrogen and the cardiovascular system.
Review in Pharmacology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
244 citing papers in PubMed, 1 synthesis or guideline pooled it, 478 citations in OpenAlex.
- The effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Social Isolation and Daily Steps Are Associated With Fatigue in Older Women With Cardiovascular Disease: A Secondary Analysis of the MindMoves Trial.Journal of aging and physical activity · 2026Trial
- Left ventricular myocardial work and its determinants in healthy subjects and the possible potential correlation with the ventricular myocardial band.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Changes in cardiometabolic risk factors in transmasculine individuals over 10 years of Gender-Affirming Hormone Therapy.Journal of endocrinological investigation · 2026Article
- Cognition in menopausal women.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Blood Pressure Changes During Aging and Menopause Among Forager-Horticulturalists in the Bolivian Amazon.American journal of biological anthropology · 2026Article
- Lifetime cumulative effect of reproductive factors, "Life's essential 8" health status and risk of chronic kidney disease: a nationwide prospective cohort study.BMC public health · 2026Article
- Clinical characteristics of hospitalized patients with benign gallbladder disease: a large-scale retrospective analysis.BMC gastroenterology · 2026Article
- An Overarching Conceptual Framework for Menstrual Health in Sport Research: Theory, Causality and Validation.Sports medicine (Auckland, N.Z.) · 2026Review
- Proteomics to reveal relationship between menstrual cycle and subjective conditions.Scientific reports · 2026Article
- Montelukast attenuates diclofenac sodium-induced cardiotoxicity in male rats via targeting Wnt/β-catenin pathway.Scientific reports · 2026Article
- Association Between Periodontitis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional Study.Clinical and experimental dental research · 2026Article
- High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANES data.Journal of global health · 2026Article
- CD207-Positive Dendritic Cells Promote Emphysema Through CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Enhanced drug disease association prediction through multimodal data integration and meta path guided global local feature fusion.Scientific reports · 2026Article
- [Radix codonopsis combined with Poria improves cognitive impairment in rats with unilateral common carotid artery ligation by regulating the ERα/PI3K/Akt signaling pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Associations of total physical activity with all-cause and cardiovascular disease mortality in Chinese adults: a prospective study.BMC public health · 2026Article
- Inducible EndothelialHypertension (Dallas, Tex. : 1979) · 2026Article
- Sex-specific cardiovascular risk prediction using AI-derived epicardial adipose tissue measurements on CT calcium scoring exams.American journal of preventive cardiology · 2026Article
- Unveiling estrogen's role: a comprehensive review of its impact on skin health and disease.Apoptosis : an international journal on programmed cell death · 2026Review
184 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated. Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which involves a membrane associated estrogen receptor(ER) and is protective, involves signaling through PI3K, Akt, and ERK 1/2. The nuclear response is much slower, as the ER-estrogen complex moves to the nucleus, where it functions as a transcription factor, both activating and repressing gene expression. Several different ERs regulate the specificity of response to estrogen, and appear to have specific effects in cardiac remodeling and the response to injury. However, much remains to be understood about the selectivity of these receptors and their specific effects on gene expression. Basic studies have demonstrated that estrogen treatment prevents apoptosis and necrosis of cardiac and endothelial cells. Estrogen also attenuates pathologic cardiac hypertrophy. Estrogen may have great benefit in aging as an anti-inflammatory agent. However, clinical investigations of estrogen have had mixed results, and not shown the clear-cut benefit of more basic investigations. This can be explained in part by differences in study design: in basic studies estrogen treatment was used immediately or shortly after ovariectomy, while in some key clinical trials, estrogen was given years after menopause. Further basic research into the underlying molecular mechanisms of estrogen's actions is essential to provide a better comprehension of the many properties of this powerful hormone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.