ReviewArchivum immunologiae et therapiae experimentalis2012
The role and regulation of mTOR in T-lymphocyte function.
Review in Archivum immunologiae et therapiae experimentalis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors.Signal transduction and targeted therapy · 2025Trial
- Whole blood transcriptome analysis in onchocerciasis.Current research in parasitology & vector-borne diseases · 2022Article
- Genomic DNA methylation profiling indicates immune response following thermal ablation treatment for HBV-associated hepatocellular carcinoma.Oncology letters · 2020Article
- Article
- mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.Scientific reports · 2016Article
- Article
- mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.Infection and immunity · 2014Article
- iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.The Journal of clinical investigation · 2014Article
- Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Role of diacylglycerol kinases in T cell development and function.Critical reviews in immunology · 2013Review
- Autophagy plays a critical role in ChLym-1-induced cytotoxicity of non-hodgkin's lymphoma cells.PloS one · 2013Article
- T cell Receptor Signal Transduction in T lymphocytes.Journal of clinical & cellular immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The conversion of naïve T cells into effector T cells is initiated by stimulation through the T-cell receptor (TCR). Upon activation, T cells undergo significant morphological and functional changes, putting new metabolic demands on the cell. Past research has identified the mammalian target of rapamycin (mTOR) as a critical regulator of cell metabolism, and the development of new genetic models has begun to reveal an important role for this pathway in the homeostasis and function of T lymphocytes. In this review, we focus on the most recent findings that demonstrate the ability of mTOR to regulate T-cell activation, CD8(+) memory cell formation and function, and helper T lineage differentiation. Furthermore, we highlight the importance of tight control of mTOR signaling by tuberous sclerosis complex 1 for T-cell homeostasis, and the regulation of mTOR signaling by diacylglycerol kinases and the RasGRP1-Ras-Erk1/2 pathway in the context of TCR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.