ArticleInternational ophthalmology2012
Initial report of quantification of retinal blood flow velocity in normal human subjects using the Retinal Functional Imager (RFI).
Article in International ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Intereye Microvascular Differences in Patients With Same-Stage Diabetic Retinopathy Revealed by OCTA.Investigative ophthalmology & visual science · 2024Article
- Stability of OCT and OCTA in the Intensive Therapy Unit Setting.Diagnostics (Basel, Switzerland) · 2021Article
- Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series.Eye and vision (London, England) · 2019Article
- Relationship between the morphology of the foveal avascular zone, retinal structure, and macular circulation in patients with diabetes mellitus.Scientific reports · 2018Article
- Retinal tissue hypoperfusion in patients with clinical Alzheimer's disease.Eye and vision (London, England) · 2018Article
- Article
- Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography.Light, science & applications · 2018Article
- Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis.Eye and vision (London, England) · 2018Article
- Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes.Eye and vision (London, England) · 2018Article
- Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.Progress in retinal and eye research · 2017Review
- Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure.Investigative ophthalmology & visual science · 2017Article
- Retinal Microvascular Network and Microcirculation Assessments in High Myopia.American journal of ophthalmology · 2017Article
- Comparison of Retinal Microvessel Blood Flow Velocities Acquired with Two Different Fields of View.Journal of ophthalmology · 2017Article
- Assessment of potential vessel segmentation pitfalls in the analysis of blood flow velocity using the Retinal Function Imager.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Conjunctival microvascular haemodynamics in sickle cell retinopathy.Acta ophthalmologica · 2015Article
- Blood flow velocity measured using the Retinal Function Imager predicts successful ranibizumab treatment in neovascular age-related macular degeneration: early prospective cohort study.Eye (London, England) · 2015Article
- The association between the foveal avascular zone and retinal thickness.Investigative ophthalmology & visual science · 2014Article
- Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Observational
- Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina.Microvascular research · 2013Article
- Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Retinal Functional Imager (RFI) is a novel method for assessing retinal blood flow (RBF) velocity. The purpose of this study was to evaluate RBF velocities in normal human retinas using the RFI. RBF velocity measurements were performed in normal subjects using the RFI (Optical Imaging Ltd., Rehovot, Israel) at the Retina Center of The New York Eye and Ear Infirmary, New York, USA. Using proprietary software processing, the characteristics of the RBF were visualized and measured. The study population comprised fifty-four eyes of 27 normal subjects (20 male and 34 female). The average arterial blood flow velocity was 4.6 ± 0.6 mm/s in males and 4.8 ± 0.7 mm/s in females (the difference was not statistically significant, p value = 0.27). The average venous blood flow velocity was 3.8 ± 0.5 mm/s in males and 3.6 ± 0.4 mm/s in females (the difference again was not statistically significant, p value = 0.11). The average arterial blood flow velocity was 4.8 ± 0.5 mm/s in the right eye and 4.6 ± 0.7 mm/s in the left eye. The average venous blood flow velocity was 3.7 ± 0.4 mm/s in the right eye and 3.6 ± 0.3 mm/s in the left eye. Venous and arterial blood flow velocities were found to be faster in the right eye than in the left eye in our sample, but the differences were not statistically significant (p value = 0.53 and 0.33, respectively). This is the first report of quantification of the RBF using the RFI. The RFI appears to be an effective tool in quantitative evaluations of RBF velocities. The values from the study constitute a normative database which can be used to evaluate and compare eyes with known or suspected pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.