ArticleJournal of molecular histology2012
Spatiotemporal patterns and essential role of TNF receptor-associated factor 5 expression after rat spinal cord Injury.
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway.Journal of neuroinflammation · 2024Article
- Downregulation of Nck1 After Spinal Cord Injury in Adult RatsBalkan medical journal · 2022Article
- Emergency 1-stage anterior approach for cervical spine infection complicated by epidural abscess.Medicine · 2017Observational
- Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord Injury.Neurochemical research · 2017Article
- Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.Cellular and molecular neurobiology · 2017Article
- PRDM5 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat.Neurochemical research · 2016Article
- Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.Journal of molecular histology · 2014Article
- Upregulated expression of SSTR1 is involved in neuronal apoptosis and is coupled to the reduction of bcl-2 following intracerebral hemorrhage in adult rats.Cellular and molecular neurobiology · 2014Article
- LIN28 expression in rat spinal cord after injury.Neurochemical research · 2014Article
- Spatiotemporal pattern of RNA-binding motif protein 3 expression after spinal cord injury in rats.Cellular and molecular neurobiology · 2014Article
- Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.Journal of molecular neuroscience : MN · 2014Article
- MCM7 expression is altered in rat after spinal cord injury.Journal of molecular neuroscience : MN · 2013Article
- Increased expression of small heat shock protein αB-crystallin after intracerebral hemorrhage in adult rats.Journal of molecular neuroscience : MN · 2013Article
- Up-regulation of Smurf1 after spinal cord injury in adult rats.Journal of molecular histology · 2013Article
- Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat.Journal of molecular histology · 2013Article
- Upregulation of myelin and lymphocyte protein (MAL) after traumatic spinal cord injury in rats.Journal of molecular histology · 2013Article
- Expression of RBMX after spinal cord injury in rats.Journal of molecular neuroscience : MN · 2013Article
- Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats.Journal of molecular histology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRAF5 (TNF receptor-associated factor 5), which has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus, was identified CD40-associated factor. It was a signal transducer for NF-κB signal pathway and other pathway. To elucidate the expression and roles of TRAF5 in nervous system lesion and repair, we performed an acute spinal cord injury (SCI) model in adult rats and studied the dynamic changes of TRAF5 expression in spinal cord. Western blot and immunohistochemistry analysis revealed that TRAF5 was present in normal spinal cord. It gradually increased, reached a peak at 5 days after SCI, and then declined during the following days. Immunofluorescence double-labeling revealed that TRAF5 was co-expressed with NeuN and GFAP, respectively. Interesting, after injury, TRAF5 expression was increased predominantly in astrocytes, which highly expressed PCNA, a marker for proliferating cells. In conclusion, this is the first description of TRAF5 expression in spinal cord. Our data suggested that TRAF5 might play important roles in CNS pathophysiology after SCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.