ArticleJournal of natural medicines2013
Rose oil (from Rosa × damascena Mill.) vapor attenuates depression-induced oxidative toxicity in rat brain.
Article in Journal of natural medicines, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Ethnopharmacology and ecosystem applications of woody plant species in the Southern European Alps: a systematic review.Frontiers in pharmacology · 2026Pooled it
- Computational screening of natural compounds from traditional Persian medicinal plant for the finding of potential antidepressant.Scientific reports · 2026Article
- Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats.Scientific reports · 2025Article
- 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds.Pharmaceutics · 2021Article
- Use of rose oil in probiotic fermented whey as a functional food.Journal of food science and technology · 2021Article
- Effects of quercetin on the alterations of serum elements in chronic unpredictable mild stress-induced depressed rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Effects of the hydroalcoholic extract of Rosa damascena on hippocampal long-term potentiation in rats fed high-fat diet.The journal of physiological sciences : JPS · 2021Article
- Rose Flowers-A Delicate Perfume or a Natural Healer?Biomolecules · 2021Review
- Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia.BMC complementary and alternative medicine · 2019Article
- Anti-stress effects of the hydroalcoholic extract ofHeliyon · 2019Article
- Novel Effects ofInternational journal of preventive medicine · 2018Article
- Effects of the hydroalcoholic extract of Rosa damascena on learning and memory in male rats consuming a high-fat diet.Pharmaceutical biology · 2017Article
- Therapeutic Applications of Rose Hips from Different Rosa Species.International journal of molecular sciences · 2017Review
- Rosa damascena as holy ancient herb with novel applications.Journal of traditional and complementary medicine · 2016Review
- Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats.Neural regeneration research · 2014Article
- Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats.Neurochemical research · 2013Article
- Therapeutic efficacy of rose oil: A comprehensive review of clinical evidence.Avicenna journal of phytomedicineReview
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is a critical route of damage in various physiological stress-induced disorders, including depression. Rose oil may be a useful treatment for depression because it contains flavonoids which include free radical antioxidant compounds such as rutin and quercetin. We investigated the effects of absolute rose oil (from Rosa × damascena Mill.) and experimental depression on lipid peroxidation and antioxidant levels in the cerebral cortex of rats. Thirty-two male rats were randomly divided into four groups. The first group was used as control, while depression was induced in the second group using chronic mild stress (CMS). Oral (1.5 ml/kg) and vapor (0.15 ml/kg) rose oil were given for 28 days to CMS depression-induced rats, constituting the third and fourth groups, respectively. The sucrose preference test was used weekly to identify depression-like phenotypes during the experiment. At the end of the experiment, cerebral cortex samples were taken from all groups. The lipid peroxidation levels in the cerebral cortex in the CMS group were higher than in control whereas their levels were decreased by rose oil vapor exposure. The vitamin A, vitamin E, vitamin C and β-carotene concentrations in the cerebral cortex were lower in the CMS group than in the control group whereas their concentrations were higher in the rose oil vapor plus CMS group. The CMS-induced antioxidant vitamin changes were not modulated by oral treatment. Glutathione peroxidase activity and reduced glutathione did not change statistically in the four groups following CMS or either treatment. In conclusion, experimental depression is associated with elevated oxidative stress while treatment with rose oil vapor induced protective effects on oxidative stress in depression.
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