ArticleInternational journal of radiation oncology, biology, physics2012
Assessment of MRI parameters as imaging biomarkers for radiation necrosis in the rat brain.
Article in International journal of radiation oncology, biology, physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Comparison of amide proton transfer imaging and methionine PET for differentiating radiation necrosis and tumor recurrence after radiotherapy: A preliminary case series.Radiology case reports · 2026Article
- Interpreting amide proton transfer-weighted imaging contrast between normal and tumor brain tissues using the asymmetry analysis method at 4.7 T.Magnetic resonance in medicine · 2026Article
- Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy.European radiology · 2025Article
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- Evaluation of Temozolomide Treatment for Glioblastoma Using Amide Proton Transfer Imaging and Diffusion MRI.Cancers · 2022Article
- Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges.Pharmaceutics · 2022Review
- Automatic method for individual parcellation of manganese-enhanced magnetic resonance imaging of rat brain.Frontiers in neuroscience · 2022Article
- Dynamic Change of Amide Proton Transfer Imaging in Irradiated Nasopharyngeal Carcinoma and Related Histopathological Mechanism.Molecular imaging and biology · 2021Article
- Amide proton transfer-weighted MRI for predicting histological grade of hepatocellular carcinoma: comparison with diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2019Article
- APT-weighted MRI: Techniques, current neuro applications, and challenging issues.Journal of magnetic resonance imaging : JMRI · 2019Review
- A retrospective dosimetry study of intensity-modulated radiotherapy for nasopharyngeal carcinoma: radiation-induced brainstem injury and dose-volume analysis.Radiation oncology (London, England) · 2018Article
- Chemical exchange saturation transfer MRI to assess cell death in breast cancer xenografts at 7T.Oncotarget · 2018Article
- Preclinical MRI: Studies of the irradiated brain.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate.Cellular and molecular neurobiology · 2018Review
- Particle Radiation Induced Neurotoxicity in the Central Nervous System.International journal of particle therapy · 2018Review
- Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas.European journal of cancer (Oxford, England : 1990) · 2017Article
- Late post-treatment radiographic changes 3 years following chemoradiation for glioma: the importance of histopathology.CNS oncology · 2017Article
- The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model.International journal of radiation biology · 2017Article
- Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging.Magnetic resonance in medicine · 2017Article
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9 authors.
Funding
Abstract
purposeRadiation necrosis is a major complication of radiation therapy. We explore the features of radiation-induced brain necrosis in the rat, using multiple MRI approaches, including T(1), T(2), apparent diffusion constant (ADC), cerebral blood flow (CBF), magnetization transfer ratio (MTR), and amide proton transfer (APT) of endogenous mobile proteins and peptides. METHODS AND MATERIALS: Adult rats (Fischer 344; n = 15) were irradiated with a single, well-collimated X-ray beam (40 Gy; 10 × 10 mm(2)) in the left brain hemisphere. MRI was acquired on a 4.7-T animal scanner at ~25 weeks' postradiation. The MRI signals of necrotic cores and perinecrotic regions were assessed with a one-way analysis of variance. Histological evaluation was accomplished with hematoxylin and eosin staining.
resultsADC and CBF MRI could separate perinecrotic and contralateral normal brain tissue (p < 0.01 and < 0.05, respectively), whereas T(1), T(2), MTR, and APT could not. MRI signal intensities were significantly lower in the necrotic core than in normal brain for CBF (p < 0.001) and APT (p < 0.01) and insignificantly higher or lower for T(1), T(2), MTR, and ADC. Histological results demonstrated coagulative necrosis within the necrotic core and reactive astrogliosis and vascular damage within the perinecrotic region.
conclusionADC and CBF are promising imaging biomarkers for identifying perinecrotic regions, whereas CBF and APT are promising for identifying necrotic cores.
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