ArticleDevelopmental cell2012
Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- MultiCell: geometric learning in multicellular development.Nature methods · 2026Article
- Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors.The EMBO journal · 2025Article
- Wnt signaling couples G2 phase control with differentiation during hematopoiesis in Drosophila.Developmental cell · 2024Article
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
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- Frequency-preference response in covalent modification cycles under substrate sequestration conditions.NPJ systems biology and applications · 2021Article
- Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021Article
- Temporal Gradients Controlling Embryonic Cell Cycle.Biology · 2021Review
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.PLoS genetics · 2020Article
- Information Thermodynamics for Time Series of Signal-Response Models.Entropy (Basel, Switzerland) · 2019Article
- Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.Cell reports · 2016Article
- Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.Developmental cell · 2016Article
- Measuring time during early embryonic development.Seminars in cell & developmental biology · 2016Review
- Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo.eLife · 2015Article
- Article
- Simple biochemical pathways far from steady state can provide switchlike and integrated responses.Biophysical journal · 2014Article
- Restricted expression of cdc25a in the tailbud is essential for formation of the zebrafish posterior body.Genes & development · 2014Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Cells commit to mitosis by abruptly activating the mitotic cyclin-Cdk complexes. During Drosophila gastrulation, mitosis is associated with the transcriptional activation of cdc25(string), a phosphatase that activates Cdk1. Here, we demonstrate that the switch-like entry into mitosis observed in the Drosophila embryo during the 14(th) mitotic cycle is timed by the dynamics of Cdc25(string) accumulation. The switch operates as a short-term integrator, a property that can improve the reliable control of timing of mitosis. The switch is independent of the positive feedback between Cdk1 and Cdc25(string) and of the double negative feedback between Cdk1 and Wee1. We propose that the properties of the mitotic switch are established by the out-of-equilibrium properties of the covalent modification cycle controlling Cdk1 activity. Such covalent modification cycles, triggered by transcriptional expression of the activating enzymes, might be a widespread strategy to obtain reliable and switch-like control of cell decisions.
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