ArticleThe journal of pain2012
Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity.
Article in The journal of pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Lysosomal Ion Channel TRPML1 Contributes to Neuropathic Pain Associated With Diabetic Peripheral Neuropathy in Mice.Diabetes · 2026Article
- Tmem45b modulates itch via endoplasmic reticulum calcium regulation.Frontiers in physiology · 2025Article
- Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Oral cancer induced TRPV1 sensitization is mediated by PARScientific reports · 2022Article
- TNFα promotes oral cancer growth, pain, and Schwann cell activation.Scientific reports · 2021Article
- Alleviating pain with delta opioid receptor agonists: evidence from experimental models.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Animal Models of Cancer-Related Pain: Current Perspectives in Translation.Frontiers in pharmacology · 2020Review
- Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain.Acta neuropathologica communications · 2019Article
- Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice.Molecular neurobiology · 2019Article
- Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.Neuroscience · 2017Article
- Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.Molecular pain · 2017Article
- Article
- The Neurobiology of Cancer Pain.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2015Review
- Article
- Neuronally produced versican V2 renders C-fiber nociceptors IB4 -positive.Journal of neurochemistry · 2015Article
- TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity.Journal of neurophysiology · 2015Article
- The neurobiology of cancer pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers.Acta neuropathologica communications · 2014Article
- IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma.Behavioral and brain functions : BBF · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledCancer patients often suffer from pain and most will be prescribed μ-opioids. μ-opioids are not satisfactory in treating cancer pain and are associated with multiple debilitating side effects. Recent studies show that μ and δ opioid receptors are separately expressed on IB4 (-) and IB4 (+) neurons, which control thermal and mechanical pain, respectively. In this study we investigated IB4 (+) and IB4 (-) neurons in mechanical and thermal hypersensitivity in an orthotopic mouse oral cancer model. We used a δ opioid receptor agonist and a P2X(3) antagonist to target IB4 (+) neurons and to demonstrate that this subset plays a key role in cancer-induced mechanical allodynia, but not in thermal hyperalgesia. Moreover, selective removal of IB4 (+) neurons using IB4-saporin impacts cancer-induced mechanical but not thermal hypersensitivity. Our results demonstrate that peripherally administered pharmacological agents targeting IB4 (+) neurons, such as a selective δ-opioid receptor agonist or P2X(3) antagonist, might be useful in treating oral cancer pain. PERSPECTIVE: To clarify the mechanisms of oral cancer pain, we examined the differential role of IB4 (+) and IB4 (-) neurons. Characterization of these 2 subsets of putative nociceptors is important for further development of effective clinical cancer pain relief.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.