ArticleBiomaterials2012
The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- Preparation and Characterization of Nanofiber Coatings on Bone Implants for Localized Antimicrobial Activity Based on Sustained Ion Release and Shape-Preserving Design.Materials (Basel, Switzerland) · 2024Article
- Flow Simulation and Gradient Printing of Fluorapatite- and Cell-Loaded Recombinant Spider Silk Hydrogels.Biomolecules · 2022Article
- Fluorapatite and fluorohydroxyapatite apatite surfaces drive adipose-derived stem cells to an osteogenic lineage.Journal of the mechanical behavior of biomedical materials · 2022Article
- Rapid structural regulation, apatite-inducing mechanism andRSC advances · 2021Article
- Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells (ASCs) osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway.Stem cell research & therapy · 2018Article
- Signals in Stem Cell Differentiation on Fluorapatite-Modified Scaffolds.Journal of dental research · 2018Article
- VEGF promotes osteogenic differentiation of ASCs on ordered fluorapatite surfaces.Journal of biomedical materials research. Part A · 2015Article
- Fluorapatite-modified scaffold on dental pulp stem cell mineralization.Journal of dental research · 2014Article
- Prevascularization of biofunctional calcium phosphate cement for dental and craniofacial repairs.Dental materials : official publication of the Academy of Dental Materials · 2014Article
- Fluorapatite enhances mineralization of mesenchymal/endothelial cocultures.Tissue engineering. Part A · 2014Article
- Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings.International journal of nanomedicine · 2014Article
- A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
In this study, the effect of ordered rod-like FA coatings of metal discs on adipose-derived stem cell (ASC)'s growth, differentiation and mineralization was studied in vitro; and their mineral inductive effects in vivo. After 3 and 7 days, the cell number on the metal surfaces was significantly higher than those on the ordered and disordered FA surfaces. However, after 4 weeks much greater amounts of mineral formation was induced on the two FA surfaces with and even without osteogenesis induction. The osteogenic profiles showed the up regulation of a set of pro-osteogenic transcripts and bone mineralization phenotypic markers when the ASCs were grown on FA surfaces compared to metal surfaces at 7 and 21 days. In addition to BMP and TGFβ signaling pathways, EGF and FGF pathways also appeared to be involved in ASC differentiation and mineralization. In vivo studies showed accelerated and enhanced mineralized tissue formation integrated within ordered FA coatings. After 5 weeks, over 80% of the ordered FA coating was integrated with a mineralized tissue layer covering the implants. Both the intrinsic properties of the FA crystals and the topography of the FA coating appeared to dominate the cell differentiation and mineralization process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.