ReviewGender medicine2012
Baroreflex function in females: changes with the reproductive cycle and pregnancy.
Review in Gender medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Acute Effects of Exercise on Blood Pressure: A Meta-Analytic Investigation.Arquivos brasileiros de cardiologia · 2016Pooled it
- Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Higher body-mass index modifies time-resolved maternal autonomic cardiac-uterine coupling during the first stage of human labour.Experimental physiology · 2026Article
- A Case of Peripartum Cardiogenic Shock Resulting From Reverse Takotsubo Cardiomyopathy.Journal of medical cases · 2026Article
- Cardiac Autonomic Balance Is Altered during the Acute Stress Response in Adolescent Major Depression-Effect of Sex.Life (Basel, Switzerland) · 2023Article
- Association between temporal patterns of baroreflex sensitivity after traumatic brain injury and prognosis: a preliminary study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Baroreflex sensitivity in facioscapulohumeral muscular dystrophy.Physiological reports · 2022Article
- Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Patterns of endogenous and exogenous ovarian hormone modulation on recovery metrics across the menstrual cycle.BMJ open sport & exercise medicine · 2021Article
- Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction.Scientific reports · 2020Article
- Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats.The Journal of physiology · 2019Article
- Systemic Outcomes of (PyrScientific reports · 2019Article
- Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.Anesthesiology · 2019Review
- Exercise for Prevention and Relief of Cardiovascular Disease: Prognoses, Mechanisms, and Approaches.Oxidative medicine and cellular longevity · 2019Review
- Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia.Clinical science (London, England : 1979) · 2016Review
- Cardiovascular Autonomic Dysfunction in Chronic Kidney Disease: a Comprehensive Review.Current hypertension reports · 2015Review
- Effect of pregnancy on the uterine vasoconstrictor response to exercise in rats.Physiological reports · 2015Article
- Should there be sex-specific criteria for the diagnosis and treatment of heart failure?Journal of cardiovascular translational research · 2014Review
- Vasopressin and oxytocin in control of the cardiovascular system.Current neuropharmacology · 2013Article
- Blood pressure and water regulation: understanding sex hormone effects within and between men and women.The Journal of physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
This review briefly describes the changes in baroreflex function that occur during female reproductive life, specifically during the reproductive cycle and pregnancy. The sensitivity or gain of baroreflex control of heart rate and sympathetic activity fluctuates during the reproductive cycle, reaching a peak when gonadal hormone levels increase, during the follicular phase in women and proestrus in rats. The increase in baroreflex sensitivity (BRS) is likely mediated by estrogen because ovariectomy in rats eliminates the BRS increase, the cyclic profile of changes in BRS mirror the changes in estrogen, and estrogen acts in the brainstem to increase BRS. In contrast, pregnancy depresses both BRS and the maximal level of sympathetic activity and heart rate evoked by severe hypotension. The decrease in BRS may be mediated by a reduction in the actions of insulin in the arcuate nucleus to support the baroreflex. In addition, increased levels of the neurosteroid progesterone metabolite 3α-OH-DHP act downstream in the rostral ventrolateral medulla to suppress maximal baroreflex increases in sympathetic activity. Consequently, these changes in baroreflex function impair blood pressure regulation in the presence of hypotensive challenges such as orthostasis and hemorrhage, a common event during delivery. As a result, peripartum hemorrhage is a major cause of human maternal death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.