Evidence map›Paper›PMID 22483118›Full record

ArticleStructure (London, England : 1993)2012

Detection of spatial correlations in protein structures and molecular complexes.

Manfred J Sippl, Markus Wiederstein

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
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  8. Review
  9. Article
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  11. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Frustration in biomolecules.Quarterly reviews of biophysics · 2014
    Review
  20. Structure-based characterization of multiprotein complexes.Structure (London, England : 1993) · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Manfred J SipplDivision of Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria. sippl@came.sbg.ac.at
Markus Wiederstein

Funding

Austrian Science Fund FWF P 21294
6 · The paper itself

Abstract

Protein structures are frequently related by spectacular and often surprising similarities. Structural correlations among protein chains are routinely detected by various structure-matching techniques, but the comparison of oligomers and molecular complexes is largely uncharted territory. Here we solve the structure-matching problem for oligomers and large molecular aggregates, including the largest molecular complexes known today. We provide several challenging examples that cannot be handled by conventional structure-matching techniques and we report on a number of remarkable correlations. The examples cover the cell-puncturing device of bacteriophage T4, the secretion system of P. aeruginosa, members of the dehydrogenase family, DNA clamps, ferredoxin iron-storage cages, and virus capsids.

Indexed as

Computer SimulationStructural Homology, ProteinBacterial ProteinsBacteriophage T4Capsid ProteinsCrystallography, X-RayDNAFerredoxinsFerritinsFungal ProteinsHumansModels, MolecularOxidoreductasesProtein MultimerizationProtein Structure, TertiaryPseudomonas aeruginosaBacterial ProteinsCapsid ProteinsDNAFerredoxinsFerritinsFungal ProteinsOxidoreductases

Identifiers

PMID22483118
PMCPMC3320710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.