ArticleDevelopmental cognitive neuroscience2012
Comparing the neural bases of self-referential processing in typically developing and 22q11.2 adolescents.
Article in Developmental cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Unpacking mentalizing: The roles of age and executive functioning in self-other appraisal and perspective taking.Quarterly journal of experimental psychology (2006) · 2025Article
- Verbal narrative ability and episodic autobiographical memory in adolescents and young adults with 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2025Article
- The bodily self from psychosis to psychedelics.Scientific reports · 2023Article
- Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome.Journal of autism and developmental disorders · 2023Article
- Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients.Schizophrenia bulletin · 2022Article
- Neural correlates of the self-concept in adolescence-A focus on the significance of friends.Human brain mapping · 2017Article
- Long-range dysconnectivity in frontal and midline structures is associated to psychosis in 22q11.2 deletion syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Negative Emotion Weakens the Degree of Self-Reference Effect: Evidence from ERPs.Frontiers in psychology · 2016Article
- On the role of the ventromedial prefrontal cortex in self-processing: the valuation hypothesis.Frontiers in human neuroscience · 2013Article
- Action simulation in hallucination-prone adolescents.Frontiers in human neuroscience · 2013Article
- Randomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorder.Frontiers in human neuroscience · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of self-reflective processing during adolescence is relevant, as this period is characterized by deep reorganization of the self-concept. It may be the case that an atypical development of brain regions underlying self-reflective processing increases the risk for psychological disorders and impaired social functioning. In this study, we investigated the neural bases of self- and other-related processing in typically developing adolescents and youths with 22q11.2 deletion syndrome (22q11DS), a rare neurogenetic condition associated with difficulties in social interactions and increased risk for schizophrenia. The fMRI paradigm consisted in judging if a series of adjectives applied to the participant himself/herself (self), to his/her best friend or to a fictional character (Harry Potter). In control adolescents, we observed that self- and other-related processing elicited strong activation in cortical midline structures (CMS) when contrasted with a semantic baseline condition. 22q11DS exhibited hypoactivation in the CMS and the striatum during the processing of self-related information when compared to the control group. Finally, the hypoactivation in the anterior cingulate cortex was associated with the severity of prodromal positive symptoms of schizophrenia. The findings are discussed in a developmental framework and in light of their implication for the development of schizophrenia in this at-risk population.
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