ArticleGastrointestinal endoscopy2012
Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos).
Article in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus.The American journal of gastroenterology · 2016Guideline
- Trial
- Efficacy and safety of Hybrid-APC for the ablation of Barrett's esophagus.Surgical endoscopy · 2016Trial
- Review
- Optical Imaging Technologies and Clinical Applications in Gastrointestinal Endoscopy.Diagnostics (Basel, Switzerland) · 2025Review
- Translating Molecular Biology Discoveries to Develop Targeted Cancer Interception in Barrett's Esophagus.International journal of molecular sciences · 2023Review
- Computer-Aided Diagnosis by Tissue Image Analysis as an Optical Biopsy in Hysteroscopy.International journal of molecular sciences · 2022Review
- An Endoscopic and Histologic Study on Healing of Radiofrequency Ablation Wounds in Patients With Barrett's Esophagus.The American journal of gastroenterology · 2022Article
- A human Barrett's esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment.Journal of biomedical optics · 2022Article
- Is Computer-Assisted Tissue Image Analysis the Future in Minimally Invasive Surgery? A Review on the Current Status of Its Applications.Journal of clinical medicine · 2021Review
- Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus.Annals of the New York Academy of Sciences · 2020Review
- Indications, contraindications and limitations of endoscopic therapy for Barrett's esophagus and early esophageal adenocarcinoma.Therapeutic advances in gastroenterology · 2020Review
- Management of Barrett Esophagus Following Radiofrequency Ablation.Gastroenterology & hepatology · 2019Article
- Durability of Endoscopic Treatment for Dysplastic Barrett's Esophagus.Current treatment options in gastroenterology · 2019Review
- Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography.Biomedical optics express · 2019Article
- Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett's Cells.Gastroenterology · 2019Article
- Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video).Gastrointestinal endoscopy · 2018Article
- Natural History of the Post-ablation Esophagus.Digestive diseases and sciences · 2018Review
- Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones.Biomedical optics express · 2018Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundRadiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples.
objectiveTo demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy.
designCross-sectional study.
settingSingle teaching hospital. PATIENTS: Twenty-six male and 1 female white patients with BE undergoing RFA treatment.
interventions3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete eradication of intestinal metaplasia (pre-CE-IM group) and in 16 patients after CE-IM (post-CE-IM group). MAIN OUTCOME MEASUREMENTS: Prevalence, size, and location of buried glands relative to the squamocolumnar junction.
results3D-OCT provided an approximately 30 to 60 times larger field of view compared with jumbo and standard biopsy and sufficient imaging depth for detecting buried glands. Based on 3D-OCT results, buried glands were found in 72% of patients (13/18) in the pre-CE-IM group and 63% of patients (10/16) in the post-CE-IM group. The number (mean [standard deviation]) of buried glands per patient in the post-CE-IM group (7.1 [9.3]) was significantly lower compared with the pre-CE-IM group (34.4 [44.6]; P = .02). The buried gland size (P = .69) and distribution (P = .54) were not significantly different before and after CE-IM. LIMITATIONS: A single-center, cross-sectional study comparing patients at different time points in treatment. Lack of 1-to-1 coregistered histology for all OCT data sets obtained in vivo.
conclusionBuried glands were frequently detected with 3D-OCT near the gastroesophageal junction before and after radiofrequency ablation.
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