Evidence map›Paper›PMID 22482707›Full record

ReviewCurrent opinion in virology2012

Structure of human adenovirus.

Glen R Nemerow, Phoebe L Stewart, Vijay S Reddy

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Mysteries of adenovirus packaging.Journal of virology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Oncolytic viruses against cancer, promising or delusion?Medical oncology (Northwood, London, England) · 2023
    Review
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Glen R NemerowThe Scripps Research Institute, La Jolla, CA 92037, United States. gnemerow@scripps.edu
Phoebe L Stewart
Vijay S Reddy
Scripps Research Institute · USVanderbilt University · US

Funding

AV INTEGRINS AND ADENOVIRUS INTERNALIZATIONR01HL054352 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 1995 to 2016
$7.5M
ROLE OF CELL INTEGRINS IN ADENOVIRAL CONJUNCTIVITISR01EY011431 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 1997 to 2012
$4.9M
X-ray diffraction analysis of human adenovirusesR01AI070771 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI REDDY, VIJAY S · 2008 to 2015
$3.3M
Cryo-EM Structural Studies of Adenovirus Cell EntryR01AI042929 · NIAID · VANDERBILT UNIVERSITY · PI STEWART, PHOEBE L · 2004 to 2010
$2.8M
X-ray diffraction analysis of human adenovirusR56AI070771 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI REDDY, VIJAY S · 2006 to 2006
$418k
CRYO-EM STRUCTURAL STUDIES OF ADENOVIRUS CELL ENTRYR29AI042929 · NIAID · VANDERBILT UNIVERSITY · PI STEWART, PHOEBE L · 1997 to 2001
$214k
NCI NIH HHS Y1-CO-1020NEI NIH HHS EY011431NEI NIH HHS R01 EY011431NHLBI NIH HHS HL054352NHLBI NIH HHS R01 HL054352NIAID NIH HHS AI042929NIAID NIH HHS AI070771NIAID NIH HHS R01 AI042929NIAID NIH HHS R01 AI070771NIAID NIH HHS R29 AI042929NIAID NIH HHS R56 AI070771NIGMS NIH HHS Y1-GM-1104
6 · The paper itself

Abstract

A detailed structural analysis of the entire human adenovirus capsid has been stymied by the complexity and size of this 150 MDa macromolecular complex. Over the past 10 years, the steady improvements in viral genome manipulation concomitant with advances in crystallographic techniques and data processing software has allowed structure determination of this virus by X-ray diffraction at 3.5 Å resolution. The virus structure revealed the location, folds, and interactions of major and minor (cement proteins) on the inner and outer capsid surface. This new structural information sheds further light on the process of adenovirus capsid assembly and virus-host cell interactions.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanAnimalsCapsidCapsid ProteinsHumansX-Ray DiffractionCapsid Proteins

Identifiers

PMID22482707
PMCPMC3322384
OpenAlexW2028068823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.