ArticleJournal of biomechanical engineering2012
Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon.
Article in Journal of biomechanical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Understanding Tendons: Lessons from Transgenic Mouse Models.Stem cells and development · 2018Pooled it
- Regulators of ECM structure enable functional adaptation to tensile loading in tendon explants.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon Explants.bioRxiv : the preprint server for biology · 2026Article
- The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice.Physiological reports · 2025Article
- Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.Journal of biomechanical engineering · 2024Article
- Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.Annals of biomedical engineering · 2024Article
- Decoding the transcriptomic expression and genomic methylation patterns in the tendon proper and its peritenon region in the aging horse.BMC research notes · 2023Article
- Guidelines for ex vivo mechanical testing of tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Investigating the temporal roles of decorin and biglycan in tendon healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- The Degradation of Intramuscular Connective Tissue In Vitro with Purified Cathepsin L from Bovine Pancreas.Foods (Basel, Switzerland) · 2023Article
- An indentation-based framework for probing the glycosaminoglycan-mediated interactions of collagen fibrils.Journal of the mechanical behavior of biomedical materials · 2023Article
- Collagen V deficiency during murine tendon healing results in distinct healing outcomes based on knockdown severity.Journal of biomechanics · 2022Article
- Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression.Matrix biology plus · 2022Article
- The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review.Journal of biomechanical engineering · 2022Review
- Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer.Nature communications · 2021Article
- Relationship between increased serum & synovial fluid decorin levels & knee osteoarthritis.The Indian journal of medical research · 2021Article
- Basic Structure, Physiology, and Biochemistry of Connective Tissues and Extracellular Matrix Collagens.Advances in experimental medicine and biology · 2021Article
- Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon.Matrix biology : journal of the International Society for Matrix Biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The interactions of small leucine-rich proteoglycans (SLRPs) with collagen fibrils, their association with water, and their role in fibrillogenesis suggests that SLRPs may play an important role in tendon mechanics. Some studies have assessed the role of SLRPs in the mechanical response of the tendon, but the relationships between sophisticated mechanics, assembly of collagen, and SLRPs have not been well characterized. Decorin content was varied in a dose dependent manner using decorin null, decorin heterozygote, and wild type mice. Quantitative measures of mechanical (tension and compression), compositional, and structural changes of the mouse patellar tendon were evaluated. Viscoelastic, tensile dynamic modulus was increased in the decorin heterozygous tendons compared to wild type. These tendons also had a significant decrease in total collagen and no structural changes compared to wild type. Decorin null tendons did not have any mechanical changes; however, a significant decrease in the average fibril diameter was found. No differences were seen between genotypes in elastic or compressive properties, and all tendons demonstrated viscoelastic mechanical dependence on strain rate and frequency. These results suggest that decorin, a member of the SLRP family, plays a role in tendon viscoelasticity that cannot be completely explained by its role in collagen fibrillogenesis. In addition, reductions in decorin do not cause large changes in indentation compressive properties, suggesting that other factors contribute to these properties. Understanding these relationships may ultimately help guide development of tissue engineered constructs or treatment modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.