Evidence map›Paper›PMID 22482024›Full record

ArticleCommunicative & integrative biology2012

Genomics of Megavirus and the elusive fourth domain of Life.

Matthieu Legendre, Defne Arslan, Chantal Abergel, Jean-Michel Claverie

Open access · goldAbstract read
In one paragraph

Article in Communicative & integrative biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Chloroviruses.Viruses · 2019
    Review
  12. Review
  13. Kinetics of Mimivirus Infection Stages Quantified Using Image Flow Cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019
    Article
  14. Review
  15. Article
  16. Article
  17. Viruses · 2018
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Matthieu LegendreInformation Génomique et Structurale; Centre National de la Recherche Scientifique-Unité Propre de Recherche 2589; Aix-Marseille University; Institut de Microbiologie de la Méditerranée; Parc Scientifique de Luminy; Case 934; Marseille, France.
Defne Arslan
Chantal Abergel
Jean-Michel Claverie
Laboratoire Information Génomique et StructuraleCentre National pour la Recherche Scientifique et Technique (CNRST) · MAColorado Association of School Executives · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently described Megavirus chilensis, a giant virus isolated off the coast of Chile, also replicating in fresh water acanthamoeba. Its 1,259,197-bp genome encodes 1,120 proteins and is the largest known viral genome. Megavirus and its closest relative Mimivirus only share 594 orthologous genes, themselves sharing only 50% of identical residues in average. Despite this divergence, comparable to the maximal divergence exhibited by bacteria within the same division (e.g., gamma proteobacteria), Megavirus retained all of the genomic features unique to Mimivirus, in particular its genes encoding key-elements of the translation apparatus, a trademark of cellular organisms. Besides homologs to the four aminoacyl-tRNA synthetases (aaRS) encoded by Mimivirus, Megavirus added three additional ones, raising the total of known virus-encoded aaRS to seven: IleRS, TrpRS, AsnRS, ArgRS, CysRS, MetRS, TyrRS. This finding strongly suggests that large DNA viruses derived from an ancestral cellular genome by reductive evolution. The nature of this cellular ancestor remains hotly debated.

Indexed as

GirusMegaviridaeShort read sequencingTree of Life

Identifiers

PMID22482024
PMCPMC3291303
OpenAlexW1974133438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.