ArticleBiomicrofluidics2012
Floating-electrode enhanced constriction dielectrophoresis for biomolecular trapping in physiological media of high conductivity.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?Biosensors · 2022Review
- On-chip microfluidic buffer swap of biological samples in-line with downstream dielectrophoresis.Electrophoresis · 2022Article
- Dielectrophoresis: Developments and applications from 2010 to 2020.Electrophoresis · 2021Review
- Review: Microbial analysis in dielectrophoretic microfluidic systems.Analytica chimica acta · 2017Review
- Refinement of insulator-based dielectrophoresis.The Analyst · 2017Article
- Nanoslit design for ion conductivity gradient enhanced dielectrophoresis for ultrafast biomarker enrichment in physiological media.Biomicrofluidics · 2016Article
- Dielectrophoresis of gold nanoparticles conjugated to DNA origami structures.Beilstein journal of nanotechnology · 2016Article
- AC Electrokinetics of Physiological Fluids for Biomedical Applications.Journal of laboratory automation · 2015Review
- On-chip DNA preconcentration in different media conductivities by electrodeless dielectrophoresis.Biomicrofluidics · 2015Article
- Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters.Mikrochimica acta · 2015Review
- Improving the binding efficiency of quartz crystal microbalance biosensors by applying the electrothermal effect.Biomicrofluidics · 2014Article
- Temporal and spatial temperature measurement in insulator-based dielectrophoretic devices.Analytical chemistry · 2014Article
- Tandem array of nanoelectronic readers embedded coplanar to a fluidic nanochannel for correlated single biopolymer analysis.Biomicrofluidics · 2014Article
- Real-time electrochemical monitoring of adenosine triphosphate in the picomolar to micromolar range using graphene-modified electrodes.Analytical chemistry · 2013Article
- Transitioning Streaming to Trapping in DC Insulator-based Dielectrophoresis for Biomolecules.Sensors and actuators. B, Chemical · 2012Article
- Tuning direct current streaming dielectrophoresis of proteins.Biomicrofluidics · 2012Article
- Preface to special topic: selected papers from the second conference on advances in microfluidics and nanofluidics and Asia-pacific international symposium on lab on chip.Biomicrofluidics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an electrokinetic framework for designing insulator constriction-based dielectrophoresis devices with enhanced ability to trap nanoscale biomolecules in physiological media of high conductivity, through coupling short-range dielectrophoresis forces with long-range electrothermal flow. While a 500-fold constriction enables field focusing sufficient to trap nanoscale biomolecules by dielectrophoresis, the extent of this high-field region is enhanced through coupling the constriction to an electrically floating sensor electrode at the constriction floor. However, the enhanced localized fields due to the constriction and enhanced current within saline media of high conductivity (1 S/m) cause a rise in temperature due to Joule heating, resulting in a hotspot region midway within the channel depth at the constriction center, with temperatures of ∼8°-10°K above the ambient. While the resulting vortices from electrothermal flow are directed away from the hotspot region to oppose dielectrophoretic trapping, they also cause a downward and inward flow towards the electrode edges at the constriction floor. This assists biomolecular trapping at the sensor electrode through enabling long-range fluid sampling as well as through localized stirring by fluid circulation in its vicinity.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.