ReviewMediators of inflammation2012
Facts and fiction: the impact of hypothermia on molecular mechanisms following major challenge.
Review in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Autophagy Behavior under Local Hypothermia in Myocardiocytes Injury.Cardiovascular & hematological agents in medicinal chemistry · 2024Review
- Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea.Antioxidants & redox signaling · 2022Article
- Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs.PloS one · 2022Article
- Neglected No More: Emerging Cellular Therapies in Traumatic Injury.Stem cell reviews and reports · 2021Review
- Eukaryotic response to hypothermia in relation to integrated stress responses.Cell stress & chaperones · 2020Review
- Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours.Acta cirurgica brasileira · 2020Article
- Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity.Frontiers in immunology · 2017Article
- Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia.Frontiers in cellular neuroscience · 2017Article
- Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice.Neurobiology of disease · 2016Article
- The Effect of Temperature Changes in Vitreoretinal Surgery.Translational vision science & technology · 2016Article
- Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs.Frontiers in medicine · 2016Article
- Relevance of induced and accidental hypothermia after trauma-haemorrhage-what do we know from experimental models in pigs?Intensive care medicine experimental · 2014Article
- Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice.Journal of neurotrauma · 2014Article
- Hypothermia: effects on platelet function and hemostasis.Thrombosis journal · 2014Article
- The role of fibrosis in Duchenne muscular dystrophy.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous multiple trauma and surgical patients suffer from accidental hypothermia. While induced hypothermia is commonly used in elective cardiac surgery due to its protective effects, accidental hypothermia is associated with increased posttraumatic complications and even mortality in severely injured patients. This paper focuses on protective molecular mechanisms of hypothermia on apoptosis and the posttraumatic immune response. Although information regarding severe trauma is limited, there is evidence that induced hypothermia may have beneficial effects on the posttraumatic immune response as well as apoptosis in animal studies and certain clinical situations. However, more profound knowledge of mechanisms is necessary before randomized clinical trials in trauma patients can be initiated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.