ReviewCellular and molecular life sciences : CMLS2012
Memory CD4+ T cells: fate determination, positive feedback and plasticity.
Review in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Fundamental Trade-Offs in the Robustness of Biological Systems with Feedback Regulation.ACS synthetic biology · 2025Article
- Comparison of stromal vascular fraction cell composition between Coleman fat and extracellular matrix/stromal vascular fraction gel.Adipocyte · 2024Article
- HIV Expression in Infected T Cell Clones.Viruses · 2024Review
- Tumor-resident memory T cells as a biomarker of the response to cancer immunotherapy.Frontiers in immunology · 2023Review
- Id3 expression identifies CD4Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Remodeling the chromatin landscape in T lymphocytes by a division of labor among transcription factors.Immunological reviews · 2021Review
- Systematic Immunophenotyping Reveals Sex-Specific Responses After Painful Injury in Mice.Frontiers in immunology · 2020Article
- Origins of CD4Immunology · 2019Review
- Effect of storage period of red blood cell suspensions on helper T-cell subpopulations.Blood transfusion = Trasfusione del sangue · 2018Article
- Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling.Cold Spring Harbor perspectives in biology · 2018Review
- Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide fromFrontiers in pharmacology · 2017Article
- CD4 T-cell memory generation and maintenance.Critical reviews in immunology · 2014Review
- Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.Current topics in microbiology and immunology · 2014Review
- Vaccine against autoimmune disease: antigen-specific immunotherapy.Current opinion in immunology · 2013Review
- Helper T-cell identity and evolution of differential transcriptomes and epigenomes.Immunological reviews · 2013Review
- Pushing the frontiers of T-cell vaccines: accurate measurement of human T-cell responses.Expert review of vaccines · 2012Review
- Cytokines of the γ(c) family control CD4+ T cell differentiation and function.Nature immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Naïve CD4(+) T cells undergo massive cell proliferation upon encountering their cognate ligand. This proliferation depends upon appropriate cues from the antigen-presenting cells that have processed the antigen and present the peptide to the T cells, and requires the establishment of a cytokine environment that can support such proliferation. Expansion of antigen-specific CD4(+) T cells needs to be coupled with differentiation into one of several effector/regulatory phenotypes if the priming event is to result in cells that can initially act to control the particular pathogen that elicited the response, and later to serve as memory cells to insure an appropriate response upon reintroduction of the pathogen. Here, we discuss the initiation of T helper lineage commitment, the positive feedback regulation by the cytokine environment to enhance and stabilize the differentiation into distinct T helper subsets, and the biological significance of CD4(+) T cell plasticity and long-term CD4(+) T cell memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.