SynthesisJournal of cancer research and clinical oncology2012
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.
Synthesis in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer.Medicine · 2019Pooled it
- Risk factors for gastric cancer in Latin America: a meta-analysis.Cancer causes & control : CCC · 2013Pooled it
- Chronic hepatitis B virus infection and the risk of extrahepatic malignancies: an updated review of epidemiology, mechanisms, and clinical implications.Virology journal · 2026Review
- Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population.Cancer research and treatment · 2019Article
- Molecular alterations in gastric cancer with special reference to the early-onset subtype.World journal of gastroenterology · 2016Review
- Article
- Helicobacter pylori in gastric carcinogenesis.World journal of gastrointestinal oncology · 2015Review
- PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies.Genes & cancer · 2015Article
- Associations of genetic variants in the PSCA, MUC1 and PLCE1 genes with stomach cancer susceptibility in a Chinese population.PloS one · 2015Article
- PSCA rs2294008 C > T polymorphism contributes to gastric and bladder cancer risk.Therapeutics and clinical risk management · 2015Article
- Screening of susceptibility genes and multi-gene risk analysis in gastric cancer.Medical oncology (Northwood, London, England) · 2014Article
- Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population.Cancer science · 2014Article
- Role of gene polymorphisms in gastric cancer and its precursor lesions: current knowledge and perspectives in Latin American countries.World journal of gastroenterology · 2014Review
- Gastric cancer-molecular and clinical dimensions.Nature reviews. Clinical oncology · 2013Review
- Prostate stem cell antigen rs2294008 polymorphism differentially contributes toMolecular and clinical oncology · 2013Article
- Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer.Journal of the National Cancer Institute · 2013Article
- Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProstate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.
methodsTo investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case-control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.
resultsFor PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35-1.91; TT vs. TC/CC: OR = 1.33, 95 % CI = 1.24-1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24-2.31; AA vs. AG/GG: OR = 1.36, 95 % CI = 1.24-1.50). In the stratified analysis by ethnicity of rs2294008, an increased gastric cancer risk was found in both Asians (TT vs. TC/CC: OR = 1.31, 95 % CI = 1.22-1.42) and Europeans (TT/TC vs. CC: OR = 1.42, 95 % CI = 1.18-1.71). Furthermore, when stratified by clinicopathologic characteristics of tumor location and histology, a higher risk on non-cardia compared with cardia gastric cancer (TT vs. TC/CC: OR = 1.43, 95 % CI = 1.12-1.83) as same as diffused compared with intestinal gastric cancer (TT vs. TC/CC: OR = 1.29, 95 % CI = 1.13-1.49) was observed.
conclusionThese findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
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