ArticleBritish journal of cancer2012
Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prognostic significance of X-linked inhibitor of apoptosis protein in patients with gastrointestinal tract cancers: A meta-analysis.Medicine · 2020Pooled it
- Article
- The power of mumps virus: Matrix protein activates apoptotic pathways in human colorectal cell lines.PloS one · 2023Article
- Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential.ACS chemical biology · 2019Review
- Prognostic Value of XIAP Level in Patients with Various Cancers: A Systematic Review and Meta-Analysis.Journal of Cancer · 2019Article
- Expression Level of Caspase Genes in Colorectal CancerAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Current medicinal chemistry · 2016Article
- Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.Journal of medicinal chemistry · 2015Article
- Cell death controlling complexes and their potential therapeutic role.Cellular and molecular life sciences : CMLS · 2015Review
- Prognostic value of Caspase-3 expression in cancers of digestive tract: a meta-analysis and systematic review.International journal of clinical and experimental medicine · 2015Review
- Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma.OncoTargets and therapy · 2015Article
- Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines.Apoptosis : an international journal on programmed cell death · 2014Article
- DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence.Apoptosis : an international journal on programmed cell death · 2014Article
- Identification of clinically relevant molecular subtypes in colorectal cancer: the dawning of a new era.The oncologist · 2014Review
- Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?Journal of molecular medicine (Berlin, Germany) · 2014Review
- Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical to successful execution of mitochondrial-mediated apoptosis is apoptosome formation and subsequent activation of caspases. Defects in this pathway have an important role in colorectal carcinogenesis and chemoresistance; therefore, the expression of apoptosome-associated proteins may be associated with clinical outcome and response to chemotherapy.
methodsHere we performed a systematic analysis of the immunohistochemical expression of the key proteins involved in apoptosome-dependent caspase activation (APAF1, Pro-caspases 9 and 3, SMAC, and XIAP) in a cohort of Stage II and III colorectal cancer patients from a Phase III trial of adjuvant 5-fluorouracil-based chemotherapy vs postoperative observation alone.
resultsSurvival analysis indicated that of the apoptosome-associated proteins examined here, Pro-caspase 3 and APAF1 have potential clinical utility as predictive markers in Stage II and III colorectal cancer, respectively. Interestingly, we identified APAF1 staining to be associated with better recurrence-free and overall survival in patients receiving chemotherapy.
conclusionThese studies reveal the importance of the apoptosome-dependent caspase activation pathway, specifically Pro-caspase 3 and APAF1 proteins, for predicting both prognosis and response to therapy.
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