ReviewProgress in retinal and eye research2012
Diverse types of ganglion cell photoreceptors in the mammalian retina.
Review in Progress in retinal and eye research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 102 citations in OpenAlex.
- A complete spatial map of mouse retinal ganglion cells reveals density and gene expression specializations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Influence of white-light-emitting diodes on primary visual cortex layer 5 pyramidal neurons (V1L5PNs) and remodeling by blue-light-blocking lenses.International ophthalmology · 2024Article
- Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates.Communications biology · 2023Review
- The effects of ambient narrowband long-wavelength light on lens-induced myopia and form-deprivation myopia in tree shrews.Experimental eye research · 2023Article
- Article
- Pupillary Light Response Deficits in 4-Week-Old Piglets and Adolescent Children after Low-Velocity Head Rotations and Sports-Related Concussions.Biomedicines · 2023Article
- Colour and melanopsin mediated responses in the murine retina.Frontiers in cellular neuroscience · 2023Article
- Differential susceptibility of retinal ganglion cell subtypes against neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Review
- Melanopsin modulates refractive development and myopia.Experimental eye research · 2022Article
- Recent Advances in Chronotherapy Targeting Respiratory Diseases.Pharmaceutics · 2021Review
- Comparative Neurology of Circadian Photoreception: The Retinohypothalamic Tract (RHT) in Sighted and Naturally Blind Mammals.Frontiers in neuroscience · 2021Review
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (Journal of toxicologic pathology · 2021Review
- Form vision from melanopsin in humans.Nature communications · 2019Article
- Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew.The Journal of comparative neurology · 2019Article
- Article
- Circadian rhythms, refractive development, and myopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2018Review
- Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology.Frontiers in neurology · 2018Review
- Psychophysical Measurements of Luminance Contrast Sensitivity and Color Discrimination with Transparent and Blue-Light Filter Intraocular Lenses.Ophthalmology and therapy · 2017Article
- ipRGCs: possible causation accounts for the higher prevalence of sleep disorders in glaucoma patients.International journal of ophthalmology · 2017Article
- Melanopsin expression is an indicator of the well-being of melanopsin-expressing retinal ganglion cells but not of their viability.Neural regeneration research · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Photoreceptors carry out the first step in vision by capturing light and transducing it into electrical signals. Rod and cone photoreceptors efficiently translate photon capture into electrical signals by light activation of opsin-type photopigments. Until recently, the central dogma was that, for mammals, all phototransduction occurred in rods and cones. However, the recent discovery of a novel photoreceptor type in the inner retina has fundamentally challenged this view. These retinal ganglion cells are intrinsically photosensitive and mediate a broad range of physiological responses such as photoentrainment of the circadian clock, light regulation of sleep, pupillary light reflex, and light suppression of melatonin secretion. Intrinsically photosensitive retinal ganglion cells express melanopsin, a novel opsin-based signaling mechanism reminiscent of that found in invertebrate rhabdomeric photoreceptors. Melanopsin-expressing retinal ganglion cells convey environmental irradiance information directly to brain centers such as the hypothalamus, preoptic nucleus, and lateral geniculate nucleus. Initial studies suggested that these melanopsin-expressing photoreceptors were an anatomically and functionally homogeneous population. However, over the past decade or so, it has become apparent that these photoreceptors are distinguishable as individual subtypes on the basis of their morphology, molecular markers, functional properties, and efferent projections. These results have provided a novel classification scheme with five melanopsin photoreceptor subtypes in the mammalian retina, each presumably with differential input and output properties. In this review, we summarize the evidence for the structural and functional diversity of melanopsin photoreceptor subtypes and current controversies in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.