ReviewBiochimica et biophysica acta2012
Complexity of RNA polymerase II elongation dynamics.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Domain acquisition enabled functional expansion of the TFIIS transcription factor family.Cell & bioscience · 2025Review
- ZmSSRP1 facilitates the progression of RNA polymerase II and is essential for kernel development in maize.The Plant cell · 2025Article
- Aberrant pre-mRNA processing in cancer.The Journal of experimental medicine · 2024Review
- Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence.Nature communications · 2024Article
- Real-time single-cell characterization of the eukaryotic transcription cycle reveals correlations between RNA initiation, elongation, and cleavage.PLoS computational biology · 2021Article
- Critical Role of Transcript Cleavage in Arabidopsis RNA Polymerase II Transcriptional Elongation.The Plant cell · 2020Article
- Measuring mRNA Decay in Budding Yeast Using Single Molecule FISH.Methods in molecular biology (Clifton, N.J.) · 2018Article
- What have single-molecule studies taught us about gene expression?Genes & development · 2016Review
- Transcription Dynamics in Living Cells.Annual review of biophysics · 2016Review
- High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics.Methods (San Diego, Calif.) · 2016Article
- Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.Nature protocols · 2015Article
- 4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells.Genome biology · 2014Article
- The transcript elongation factor SPT4/SPT5 is involved in auxin-related gene expression in Arabidopsis.Nucleic acids research · 2014Article
- RNA polymerase II transcription elongation control.Chemical reviews · 2013Review
- Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Molecular biology of the cell · 2013Article
- RMP plays distinct roles in the proliferation of hepatocellular carcinoma cells and normal hepatic cells.International journal of biological sciences · 2013Article
- Defining the divergent enzymatic properties of RNA polymerases I and II.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Transcription of protein-coding genes by RNA polymerase II can be regulated at multiple points during the process of RNA synthesis, including initiation, elongation, and termination. In vivo data suggests that elongating polymerases exhibit heterogeneity throughout the gene body, suggestive of changes in elongation rate and/or pausing. Here, we review evidence from a variety of different experimental approaches for understanding regulation of transcription elongation. We compare steady-state measurements of nascent RNA density and polymerase occupancy to time-resolved measurements and point out areas of disagreement. Finally, we discuss future avenues of investigation for understanding this critically important step in gene regulation. This article is part of a Special Issue entitled: Chromatin in time and space.
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Registered trials
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