Evidence map›Paper›PMID 22480738›Full record

ArticleOphthalmology2012

Fear of falling and visual field loss from glaucoma.

Pradeep Y Ramulu, Suzanne W van Landingham, Robert W Massof, Emilie S Chan, Luigi Ferrucci, David S Friedman

Registry-linked trialAbstract read
In one paragraph

Article in Ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06692205 (Exploring the Effects of Primary Open-Angle Glaucoma on Visual-Motor Coordination), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06692205 unknown statusnot on this mapstarted 2024, after this paper: background citation

Exploring the Effects of Primary Open-Angle Glaucoma on Visual-Motor Coordination

TypeobservationalSponsorZhongshan Ophthalmic Center, Sun Yat-sen UniversityRan2024 to 2025Enrolled200ConditionsPrimary Open-angle Glaucoma
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Article
  7. Conjunctival Venular Hemodynamic Biomarkers in Glaucoma.Translational vision science & technology · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pradeep Y RamuluWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA. pramulu1@jhmi.edu
Suzanne W van Landingham
Robert W Massof
Emilie S Chan
Luigi Ferrucci
David S Friedman

Funding

Optimizing Safety and Functionality in the Visually ImpairedR01EY022976 · NEI · JOHNS HOPKINS UNIVERSITY · PI RAMULU, PRADEEP YAMMANURU · 2013 to 2024
$5.2M
Direct evaluation of functional impairment in glaucoma.K23EY018595 · NEI · JOHNS HOPKINS UNIVERSITY · PI RAMULU, PRADEEP YAMMANURU · 2009 to 2012
$876k
Intramural NIH HHSNEI NIH HHS EY018595NEI NIH HHS K23 EY018595NEI NIH HHS R01 EY022976
6 · The paper itself

Abstract

objectiveTo determine if visual field (VF) loss resulting from glaucoma is associated with greater fear of falling.

designProspective, observational study.

participantsFear of falling was compared between 83 glaucoma subjects with bilateral VF loss and 60 control subjects with good visual acuity and without significant VF loss recruited from patients followed up for suspicion of glaucoma.

methodsParticipants completed the University of Illinois at Chicago Fear of Falling Questionnaire. The extent of fear of falling was assessed using Rasch analysis.

main outcome measuresSubject ability to perform tasks without fear of falling was expressed in logits, with lower scores implying less ability and greater fear of falling.

resultsGlaucoma subjects had greater VF loss than control subjects (median better-eye mean deviation [MD] of -8.0 decibels [dB] vs. +0.2 dB; P<0.001), but did not differ with regard to age, race, gender, employment status, the presence of other adults in the home, body mass index (BMI), grip strength, cognitive ability, mood, or comorbid illness (P ≥ 0.1 for all). In multivariate models, glaucoma subjects reported greater fear of falling as compared with controls (β = -1.20 logits; 95% confidence interval [CI], -1.87 to -0.53; P = 0.001), and fear of falling increased with greater VF loss severity (β = -0.52 logits per 5-dB decrement in the better eye VF MD; 95% CI, -0.72 to -0.33; P<0.001). Other variables predicting greater fear of falling included female gender (β = -0.55 logits; 95% CI, -1.03 to -0.06; P = 0.03), higher BMI (β = -0.07 logits per 1-unit increase in BMI; 95% CI, -0.13 to -0.01; P = 0.02), living with another adult (β = -1.16 logits; 95% CI, -0.34 to -1.99 logits; P = 0.006), and greater comorbid illness (β = -0.53 logits/1 additional illness; 95% CI, -0.74 to -0.32; P<0.001).

conclusionsBilateral VF loss resulting from glaucoma is associated with greater fear of falling, with an impact that exceeds numerous other risk factors. Given the physical and psychological repercussions associated with fear of falling, significant quality-of-life improvements may be achievable in patients with VF loss by screening for, and developing interventions to minimize, fear of falling.

Indexed as

Accidental FallsVisual FieldsActivities of Daily LivingAgedAlgorithmsFearFemaleGlaucomaHealth Status IndicatorsHumansMaleProspective StudiesQuality of LifeRisk FactorsSeverity of Illness IndexSurveys and Questionnaires

Identifiers

PMID22480738
PMCPMC3389306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.