Evidence map›Paper›PMID 22480666›Full record

ArticleDrug and alcohol dependence2012

Increases in the availability of prescribed opioids in a Canadian setting.

B Nosyk, B D L Marshall, B Fischer, J S G Montaner, E Wood, T Kerr

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Increasing diversion of methadone in Vancouver, Canada, 2005-2015.Journal of substance abuse treatment · 2018
    Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B NosykBritish Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, University of British Columbia, 608-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. bnosyk@cfenet.ubc.ca
B D L Marshall
B Fischer
J S G Montaner
E Wood
T Kerr

Funding

SYRINGE ACCESS AND RISK FACTORS ON HIV TRANSMISSIONR01DA011591 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI KERR, THOMAS · 1998 to 2014
$5.9M
A Comparison of Methadone Treatment Systems in California and British ColumbiaR01DA031727 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOSYK, BOHDAN · 2011 to 2013
$512k
CIHR RAA-79918NIDA NIH HHS R01 DA011591NIDA NIH HHS R01-DA011591NIDA NIH HHS R01 DA031727NIDA NIH HHS R01-DA031727-01
6 · The paper itself

Abstract

backgroundThe nonmedical use of prescribed opioids (POs) has increased across North America over the past decade. Our objective was to identify changes in the availability of POs and other illicit drugs among drug users in a Canadian setting.

methodsInformation on the availability of illicit drugs was collected in standardized interviews from a large observational research program involving illicit drug users in Vancouver, British Columbia from 2006 to 2010. The primary outcome was the perceived availability of a set of six POs (aspirin/oxycodone, hydromorphone, oxycodone, morphine, acetaminophen/codeine and methadone) among individuals reporting ever using POs. Availability was measured in three levels: not available, delayed availability (available ≥10 min), and immediate availability (available <10 min). Multivariate ordinal logistic regression models were executed to estimate the trend in PO availability, controlling for individual characteristics hypothesized to influence availability.

results1871 individuals were followed during the study period (2006-2010), including 583 (31.2%) women. The availability of POs increased over time, regardless of changes in the characteristics of cohort entrants. These increases were observed while the availability of traditional drugs of abuse (e.g., heroin and cocaine) remained constant. The adjusted odds of delayed availability vs. unavailability were between 34% (hydromorphone) and 71% (acetaminophen/codeine) greater in each calendar year. DISCUSSION: The availability of POs among drug users in a Canadian setting increased markedly over a relatively short timeframe, despite persistent and high availability of heroin and cocaine. Further study is required to determine the context of use of POs, associated harms, as well as policy responses to increasing availability.

Indexed as

Analgesics, OpioidPrescription DrugsAdultBritish ColumbiaCanadaCohort StudiesFemaleHumansMaleMiddle AgedMultivariate AnalysisOpioid-Related DisordersProspective StudiesYoung AdultAnalgesics, OpioidPrescription Drugs

Identifiers

PMID22480666
PMCPMC3394911

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.