ArticleThe Journal of allergy and clinical immunology2012
Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 252 citations in OpenAlex.
- The adverse reactions to vaccines practice parameter 10 years on-what have we learned?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Guideline
- Flow Cytometry in Human Cells Exposed to Tick Salivary Proteins.Methods in molecular biology (Clifton, N.J.) · 2027Article
- The Humanized Mouse Model of AGS: A Preclinical System for Analyzing Hypersensitivity to α-Gal and Potential Allergenic Epitopes.Methods in molecular biology (Clifton, N.J.) · 2027Article
- High-density contrast echocardiography for patent foramen ovale assessment: sensitivity and relationship with invasively measured shunt severity and atrial septum morphology.Echo research and practice · 2026Article
- Meat allergy: Specific reactions to chicken, beef, pork, and alternative protein sources.Asia Pacific allergy · 2026Review
- From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome.Frontiers in immunology · 2026Review
- Ticked Off: Allergic Effector Cells in the Pathogenesis of Alpha-gal Syndrome.Current allergy and asthma reports · 2025Review
- Food Anaphylaxis: Eight Food Allergens Without Mandatory Labelling Highlighted by the French Allergy-Vigilance Network.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- A Review of Alpha-Gal Syndrome for the Infectious Diseases Practitioner.Open forum infectious diseases · 2025Review
- Alpha-gal allergy in a South Asian country.BMC immunology · 2025Article
- Article
- Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection.Scientific reports · 2025Article
- Allergenic potency of various foods of mammalian origin in patients with α-Gal syndrome.Allergy · 2025Article
- Alpha-Gal Syndrome: An Underrated Serious Disease and a Potential Future Challenge.Global challenges (Hoboken, NJ) · 2024Review
- Review
- Evaluation of a hydroxyapatite-crosslinked fish gelatin membranes.Journal of dental sciences · 2024Article
- The α-Gal epitope - the cause of a global allergic disease.Frontiers in immunology · 2024Review
- Review
- Alpha-gal syndrome-Food or drug allergy: A case report.Clinical case reports · 2023Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWe have observed patients clinically allergic to red meat and meat-derived gelatin.
objectiveWe describe a prospective evaluation of the clinical significance of gelatin sensitization, the predictive value of a positive test result, and an examination of the relationship between allergic reactions to red meat and sensitization to gelatin and galactose-α-1,3-galactose (α-Gal).
methodsAdult patients evaluated in the 1997-2011 period for suspected allergy/anaphylaxis to medication, insect venom, or food were skin tested with gelatin colloid. In vitro (ImmunoCAP) testing was undertaken where possible.
resultsPositive gelatin test results were observed in 40 of 1335 subjects: 30 of 40 patients with red meat allergy (12 also clinically allergic to gelatin), 2 of 2 patients with gelatin colloid-induced anaphylaxis, 4 of 172 patients with idiopathic anaphylaxis (all responded to intravenous gelatin challenge of 0.02-0.4 g), and 4 of 368 patients with drug allergy. Test results were negative in all patients with venom allergy (n = 241), nonmeat food allergy (n = 222), and miscellaneous disorders (n = 290). ImmunoCAP results were positive to α-Gal in 20 of 24 patients with meat allergy and in 20 of 22 patients with positive gelatin skin test results. The results of gelatin skin testing and anti-α-Gal IgE measurements were strongly correlated (r = 0.46, P < .01). α-Gal was detected in bovine gelatin colloids at concentrations of approximately 0.44 to 0.52 μg/g gelatin by means of inhibition RIA.
conclusionMost patients allergic to red meat were sensitized to gelatin, and a subset was clinically allergic to both. The detection of α-Gal in gelatin and correlation between the results of α-Gal and gelatin testing raise the possibility that α-Gal IgE might be the target of reactivity to gelatin. The pathogenic relationship between tick bites and sensitization to red meat, α-Gal, and gelatin (with or without clinical reactivity) remains uncertain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.