ArticleBioorganic & medicinal chemistry letters2012
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry.
Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Carbonic Anhydrase-IX Guided Albumin Nanoparticles for Hypoxia-mediated Triple-Negative Breast Cancer Cell Killing and Imaging of Patient-derived Tumor.Molecules (Basel, Switzerland) · 2020Article
- Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery.ACS omega · 2018Article
- Review
- Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium.Chemical science · 2015Article
- Engineered biomaterials for development of nucleic acid vaccines.Biomaterials research · 2015Article
- Copper-granule-catalyzed microwave-assisted click synthesis of polyphenol dendrimers.The Journal of organic chemistry · 2013Article
- Nitric oxide-releasing amphiphilic poly(amidoamine) (PAMAM) dendrimers as antibacterial agents.Biomacromolecules · 2013Article
- Molecular recognition by gold, silver and copper nanoparticles.World journal of biological chemistry · 2013Article
- Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer.Polymer · 2013Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The facile conjugation of three azido modified functionalities, namely a therapeutic drug (methotrexate), a targeting moiety (folic acid), and an imaging agent (fluorescein) with a G5 PAMAM dendrimer scaffold with cyclooctyne molecules at the surface through copper-free click chemistry is reported. Mono-, di-, and tri-functional PAMAM dendrimer conjugates can be obtained via combinatorial mixing of different azido modified functionalities simultaneously or sequentially with the dendrimer platform. Preliminary flow cytometry results indicate that the folic acid targeted nanoparticles are efficiently binding with KB cells.
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Registered trials
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