Evidence map›Paper›PMID 22480341›Full record

Trial reportBMC family practice2012

An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes.

Andrew Farmer, Wendy Hardeman, Dyfrig Hughes, A Toby Prevost, Youngsuk Kim, Anthea Craven, Jason Oke, Sue Boase, Mary Selwood, Ian Kellar and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC family practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 10 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 10 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  2. Decision coaching for people making healthcare decisions.The Cochrane database of systematic reviews · 2021
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  13. Does electronic monitoring influence adherence to medication? Randomized controlled trial of measurement reactivity.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Andrew FarmerDepartment of Primary Health Care Sciences, University of Oxford, Oxford, UK. andrew.farmer@phc.ox.ac.uk
Wendy Hardeman
Dyfrig Hughes
A Toby Prevost
Youngsuk Kim
Anthea Craven
Jason Oke
Sue Boase
Mary Selwood
Ian Kellar
Jonathan Graffy
Simon Griffin
Stephen Sutton
Ann-Louise Kinmonth
University of Cambridge · GBUniversity of Oxford · GBBangor University · GBKing's College London · GBMRC Epidemiology Unit · GB

Funding

Department of HealthMedical Research Council G0500267Medical Research Council G0800792Medical Research Council MC_U106179474
6 · The paper itself

Abstract

backgroundFailure to take medication reduces the effectiveness of treatment leading to increased morbidity and mortality. We evaluated the efficacy of a consultation-based intervention to support objectively-assessed adherence to oral glucose lowering medication (OGLM) compared to usual care among people with type 2 diabetes.

methodsThis was a parallel group randomised trial in adult patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol), prescribed at least one OGLM. Participants were allocated to a clinic nurse delivered, innovative consultation-based intervention to strengthen patient motivation to take OGLM regularly and support medicine taking through action-plans, or to usual care. The primary outcome was the percentage of days on which the prescribed dose of medication was taken, measured objectively over 12 weeks with an electronic medication-monitoring device (TrackCap, Aardex, Switzerland). The primary analysis was intention-to-treat.

results211 patients were randomised between July 1, 2006 and November 30, 2008 in 13 British general practices (primary care clinics). Primary outcome data were available for 194 participants (91.9%). Mean (sd) percentage of adherent days was 77.4% (26.3) in the intervention group and 69.0% (30.8) in standard care (mean difference between groups 8.4%, 95% confidence interval 0.2% to 16.7%, p = 0.044). There was no significant adverse impact on functional status or treatment satisfaction.

conclusionsThis well-specified, theory based intervention delivered in a single session of 30 min in primary care increased objectively measured medication adherence, with no adverse effect on treatment satisfaction. These findings justify a definitive trial of this approach to improving medication adherence over a longer period of time, with clinical and cost-effectiveness outcomes to inform clinical practice.

Indexed as

Referral and ConsultationAgedBlood GlucoseDecision Support TechniquesDiabetes Mellitus, Type 2Drug MonitoringEnglandFemaleHealth Status IndicatorsHealth SurveysHumansHypoglycemic AgentsMaleMiddle AgedOutcome Assessment, Health CarePatient ComplianceBlood GlucoseHypoglycemic Agents

Identifiers

PMID22480341
PMCPMC3499458
OpenAlexW2075370038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.