Trial reportBMC musculoskeletal disorders2012
Local biochemical and morphological differences in human Achilles tendinopathy: a case control study.
Trial report in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A systematic review of inflammatory cells and markers in human tendinopathy.BMC musculoskeletal disorders · 2020Pooled it
- Profibrotic mediators in tendon disease: a systematic review.Arthritis research & therapy · 2016Pooled it
- Proteomics perspectives in rotator cuff research: a systematic review of gene expression and protein composition in human tendinopathy.PloS one · 2015Pooled it
- Ultrasound-guided platelet-rich plasma versus corticosteroid injection for supraspinatus tendinopathy: a randomized comparative study.BMC musculoskeletal disorders · 2026Trial
- Different Achilles Tendon Pathologies Show Distinct Histological and Molecular Characteristics.International journal of molecular sciences · 2018Trial
- Quantitative Sodium MRI of the Human Patellar Tendon.NMR in biomedicine · 2026Article
- Transcriptional Adaptations to Muscle Loading in a Murine Model of Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Severe knee osteoarthritis is associated with histological and ultrastructural changes in the semitendinosus tendon.Journal of experimental orthopaedics · 2025Article
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Characterization of anMatrix biology plus · 2024Article
- Quantitative Analysis of Supraspinatus Tendon Pathologies via T2/T2* Mapping Techniques with 1.5 T MRI.Diagnostics (Basel, Switzerland) · 2023Article
- Genetic Determinants of the Anterior Cruciate Ligament Rupture in Sport: An Up-to-Date Systematic Review.Journal of human kinetics · 2023Article
- The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons.International journal of molecular sciences · 2021Article
- More histologic and ultrastructural degenerative signs in the subscapularis tendon and the joint capsule in male patients with shoulder impingement.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- The effects of substance P and acetylcholine on human tenocyte proliferation converge mechanistically via TGF-β1.PloS one · 2017Article
- Tendinopathy: Investigating the Intersection of Clinical and Animal Research to Identify Progress and Hurdles in the Field.JBJS reviews · 2016Article
- Changes in dermal matrix in the absence of Rac1 in keratinocytes.Journal of anatomy · 2016Article
- Inflammatory and Metabolic Alterations of Kager's Fat Pad in Chronic Achilles Tendinopathy.PloS one · 2015Article
- Regional molecular and cellular differences in the female rabbit Achilles tendon complex: potential implications for understanding responses to loading.Journal of anatomy · 2014Article
- 3-D ultrastructure and collagen composition of healthy and overloaded human tendon: evidence of tenocyte and matrix buckling.Journal of anatomy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.
methodsThirty Achilles tendinopathy patients were randomized to an expression-study (n = 16) or a structural-study (n = 14). Biopsies from two areas in the Achilles tendon were taken and structural parameters: fibril density, fibril size, volume fraction of cells and the nucleus/cytoplasm ratio of cells were determined. Further gene expressions of various genes were analyzed.
resultsSignificantly smaller collagen fibrils and a higher volume fraction of cells were observed in the tendinopathic region of the tendon. Markers for collagen and its synthesis collagen 1, collagen 3, fibronectin, tenascin-c, transforming growth factor-β fibromodulin, and markers of collagen breakdown matrix metalloproteinase-2, matrix metalloproteinase-9 and metallopeptidase inhibitor-2 were significantly increased in the tendinopathic region. No altered expressions of markers for fibrillogenesis, inflammation or wound healing were observed.
conclusionThe present study indicates that an increased expression of factors stimulating the turnover of connective tissue is present in the diseased part of tendinopathic tendons, associated with an increased number of cells in the injured area as well as an increased number of smaller and thinner fibrils in the diseased tendon region. As no fibrillogenesis, inflammation or wound healing could be detected, the present data supports the notion that tendinopathy is an ongoing degenerative process.
trial registrationCurrent Controlled Trials ISRCTN20896880.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.