ArticleCritical care (London, England)2012
GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Understanding the relationship between lung GABABMC pulmonary medicine · 2026Article
- Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidCell death & disease · 2025Article
- Remimazolam mitigates oxidative stress response in patients undergoing one-lung ventilation.Frontiers in surgery · 2025Article
- The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19.Biomedicines · 2023Review
- Glutamine-Driven Metabolic Adaptation to COVID-19 Infection.Indian journal of clinical biochemistry : IJCB · 2023Article
- Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia.Metabolites · 2022Article
- Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.Developmental cell · 2022Article
- Disturbed lipid and amino acid metabolisms in COVID-19 patients.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Comprehensive Targeted Metabolomic Study in the Lung, Plasma, and Urine of PPE/LPS-Induced COPD Mice Model.International journal of molecular sciences · 2022Article
- Mapping the metabolomic and lipidomic changes in the bleomycin model of pulmonary fibrosis in young and aged mice.Disease models & mechanisms · 2022Article
- A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice.Frontiers in immunology · 2022Article
- GABAViruses · 2021Article
- The Emerging Roles of π Subunit-Containing GABAInternational journal of medical sciences · 2021Review
- GABA administration prevents severe illness and death following coronavirus infection in mice.bioRxiv : the preprint server for biology · 2020Article
- Adaptive Support Ventilation Attenuates Ventilator Induced Lung Injury: Human and Animal Study.International journal of molecular sciences · 2019Article
- Argon reduces the pulmonary vascular tone in rats and humans by GABA-receptor activation.Scientific reports · 2019Article
- Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.PloS one · 2015Article
- Year in review 2012: Critical Care--Respirology.Critical care (London, England) · 2013Review
- Review
- Nutrition of the critically ill - emphasis on liver and pancreas.Hepatobiliary surgery and nutrition · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionMechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are involved in alveolar-fluid homeostasis. The present study investigated the role of GABA receptors in ventilator-induced lung injury.
methodsAdult female Sprague-Dawley rats were subjected to high-tidal-volume ventilation of 40 ml/kg body weight for 1 hour, and lung injuries were assessed.
resultsHigh-tidal-volume ventilation resulted in lung injury, as indicated by an increase in total protein in bronchoalveolar fluid, wet-to-dry ratio (indication of pulmonary edema), and Evans Blue dye extravasation (indication of vascular damage). Intratracheal administration of GABA before ventilation significantly reduced the wet-to-dry ratio. Further, histopathologic analysis indicated that GABA reduced ventilator-induced lung injury and apoptosis. GABA-mediated reduction was effectively blocked by the GABAA-receptor antagonist, bicuculline. The GABA-mediated effect was not due to the vascular damage, because no differences in Evans Blue dye extravasation were noted. However, the decrease in alveolar fluid clearance by high-tidal-volume ventilation was partly prevented by GABA, which was blocked by bicuculline.
conclusionsThese results suggest that GABA reduces pulmonary edema induced by high-tidal-volume ventilation via its effects on alveolar fluid clearance and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.