Evidence map›Paper›PMID 22479687›Full record

ArticleMobile genetic elements2011

Association of a centromere specific nucleosome with the yeast plasmid partitioning locus: Implications beyond plasmid partitioning.

Makkuni Jayaram

Open access · bronzeAbstract read
In one paragraph

Article in Mobile genetic elements, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Makkuni JayaramSection of Molecular Genetics and Microbiology; University of Texas at Austin; Austin, TX USA.
Laboratory of Molecular Genetics · PL

Funding

Stable Maintenance of an Extrachromosomal Selfish DNA ElementR01GM064363 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI JAYARAM, MAKKUNI · 2002 to 2010
$2.2M
NIGMS NIH HHS R01 GM064363
6 · The paper itself

Abstract

The genetically defined point centromeres of budding yeasts and the epigenetically specified regional centromeres of all other eukaryotes harbor a common epigenetic mark in the form of a non-standard nucleosome. Although, the composition of the protein core of the centromere specific nucleosome and the nature of the DNA wrap around it are at present controversial, there is no doubt that this specialized nucleosome harbors a variant of the standard histone H3 (cenH3). The association of cenH3, called Cse4 in Saccharomyces cerevisiae, with the partitioning locus (STB) of the high copy selfish plasmid 2 micron circle that resides in the yeast nucleus and propagates itself stably is intriguing. Recent observations are consistent with Cse4 being a nucleosome component at STB. A common nucleosome identity for the partitioning loci of the chromosomes and the plasmid of yeast support arguments based on evolutionary considerations that the origin of the unusual point centromere of budding yeasts may be traced to the STB locus of an ancestral plasmid.

Identifiers

PMID22479687
PMCPMC3312302
OpenAlexW2036693182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.