ReviewPLoS neglected tropical diseases2012
Many neglected tropical diseases may have originated in the Paleolithic or before: new insights from genetics.
Review in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- A Review of Traditional, Time-Honoured Foods and Recipes: To Choose to Use or Not to Use.Foods (Basel, Switzerland) · 2025Review
- After me, the deluge: The intricacies of pulmonary surfactant.Biomedical journal · 2021Article
- Prospects of Immunology Education and Research in Developing Countries.Frontiers in public health · 2021Review
- The Role of aDNA in Understanding the Coevolutionary Patterns of Human Sexually Transmitted Infections.Genes · 2018Review
- Ecology and Evolution of Chromosomal Gene Transfer between Environmental Microorganisms and Pathogens.Microbiology spectrum · 2018Article
- Cutaneous Mycobacterial Infections.Clinical microbiology reviews · 2018Review
- Ancient oncogenesis, infection and human evolution.Evolutionary applications · 2017Review
- Linking the Microbiota, Chronic Disease, and the Immune System.Trends in endocrinology and metabolism: TEM · 2016Review
- Unsolved matters in leprosy: a descriptive review and call for further research.Annals of clinical microbiology and antimicrobials · 2016Review
- Molecular analysis of ancient caries.Proceedings. Biological sciences · 2014Article
- Genomics, the origins of agriculture, and our changing microbe-scape: time to revisit some old tales and tell some new ones.American journal of physical anthropology · 2013Review
- Estimating divergence times in large molecular phylogenies.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Phylogenetic evidence that two distinct Trichuris genotypes infect both humans and non-human primates.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The standard view of modern human infectious diseases is that many of them arose during the Neolithic when animals were first domesticated, or afterwards. Here we review recent genetic and molecular clock estimates that point to a much older Paleolithic origin (2.5 million years ago to 10,000 years ago) of some of these diseases. During part of this ancient period our early human ancestors were still isolated in Africa. We also discuss the need for investigations of the origin of these diseases in African primates and other animals that have been the original source of many neglected tropical diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.