ArticlePloS one2012
Comparative analysis of gene content evolution in phytoplasmas and mycoplasmas.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Draft genome sequences and comparative analyses of Spiroplasma citri strains from various hosts.Folia microbiologica · 2026Article
- Phytoplasma Genome Reconstruction: From DNA Enrichment to Sequencing and Genome Assembly.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Comparative Genome Analysis of 'Frontiers in microbiology · 2022Article
- Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials.Antibiotics (Basel, Switzerland) · 2021Review
- Rapid molecular evolution ofMicrobial genomics · 2021Article
- Bacterial Vector-Borne Plant Diseases: Unanswered Questions and Future Directions.Molecular plant · 2020Review
- Synergism between the Black Queen effect and the proteomic constraint on genome size reduction in the photosynthetic picoeukaryotes.Scientific reports · 2020Article
- Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes.Biomolecules · 2020Article
- Species Boundaries and Molecular Markers for the Classification of 16SrI Phytoplasmas Inferred by Genome Analysis.Frontiers in microbiology · 2020Article
- Multilocus Sequence Analysis Reveals Three Distinct Populations of "Applied and environmental microbiology · 2019Article
- Genomic Characterization of the Periwinkle Leaf Yellowing (PLY) Phytoplasmas in Taiwan.Frontiers in microbiology · 2019Article
- Winding paths to simplicity: genome evolution in facultative insect symbionts.FEMS microbiology reviews · 2016Review
- Coconut Lethal Yellowing Diseases: A Phytoplasma Threat to Palms of Global Economic and Social Significance.Frontiers in plant science · 2016Review
- The small phytoplasma virulence effector SAP11 contains distinct domains required for nuclear targeting and CIN-TCP binding and destabilization.The New phytologist · 2014Article
- Molecular evolution of the substrate utilization strategies and putative virulence factors in mosquito-associated Spiroplasma species.Genome biology and evolution · 2014Article
- Horizontal transfer of potential mobile units in phytoplasmas.Mobile genetic elements · 2013Article
- Genomes of the class Erysipelotrichia clarify the firmicute origin of the class Mollicutes.International journal of systematic and evolutionary microbiology · 2013Article
- New insights on the biology of swine respiratory tract mycoplasmas from a comparative genome analysis.BMC genomics · 2013Article
- Comparative genome analysis of Spiroplasma melliferum IPMB4A, a honeybee-associated bacterium.BMC genomics · 2013Article
- Comparison of metabolic capacities and inference of gene content evolution in mosquito-associated Spiroplasma diminutum and S. taiwanense.Genome biology and evolution · 2013Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoplasmas and mycoplasmas are two groups of important pathogens in the bacterial class Mollicutes. Because of their economical and clinical importance, these obligate pathogens have attracted much research attention. However, difficulties involved in the empirical study of these bacteria, particularly the fact that phytoplasmas have not yet been successfully cultivated outside of their hosts despite decades of attempts, have greatly hampered research progress. With the rapid advancements in genome sequencing, comparative genome analysis provides a new approach to facilitate our understanding of these bacteria. In this study, our main focus is to investigate the evolution of gene content in phytoplasmas, mycoplasmas, and their common ancestor. By using a phylogenetic framework for comparative analysis of 12 complete genome sequences, we characterized the putative gains and losses of genes in these obligate parasites. Our results demonstrated that the degradation of metabolic capacities in these bacteria has occurred predominantly in the common ancestor of Mollicutes, prior to the evolutionary split of phytoplasmas and mycoplasmas. Furthermore, we identified a list of genes that are acquired by the common ancestor of phytoplasmas and are conserved across all strains with complete genome sequences available. These genes include several putative effectors for the interactions with hosts and may be good candidates for future functional characterization.
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