ArticlePloS one2012
Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer.Epigenetics · 2024Article
- Higher Expressions of SHH and AR Are Associated with a Positive Receptor Status and Have Impact on Survival in a Cohort of Croatian Breast Cancer Patients.Life (Basel, Switzerland) · 2022Article
- Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment.Diagnostics (Basel, Switzerland) · 2021Article
- Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis.Journal of mammary gland biology and neoplasia · 2020Review
- Article
- Review
- Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy.International journal of molecular sciences · 2018Article
- Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis.Scientific reports · 2017Article
- Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.Scientific reports · 2017Article
- What Is Breast in the Bone?International journal of molecular sciences · 2016Review
- Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment.Molecular cancer · 2016Review
- A microRNA code for prostate cancer metastasis.Oncogene · 2016Article
- The Role of Prolactin in Bone Metastasis and Breast Cancer Cell-Mediated Osteoclast Differentiation.Journal of the National Cancer Institute · 2016Article
- Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells.Cell death & disease · 2016Article
- Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.Advanced drug delivery reviews · 2014Review
- Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.Molecular endocrinology (Baltimore, Md.) · 2014Article
- BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways.BMC cancer · 2014Article
- Role of osteopontin in the pathophysiology of cancer.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Emerging targeted agents in metastatic breast cancer.Nature reviews. Clinical oncology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The remodeling process in bone yields numerous cytokines and chemokines that mediate crosstalk between osteoblasts and osteoclasts and also serve to attract and support metastatic tumor cells. The metastatic tumor cells disturb the equilibrium in bone that manifests as skeletal complications. The Hedgehog (Hh) pathway plays an important role in skeletogenesis. We hypothesized that the Hh pathway mediates an interaction between tumor cells and osteoblasts and influences osteoblast differentiation in response to tumor cells. We have determined that breast tumor cells have an activated Hh pathway characterized by upregulation of the ligand, IHH and transcription factor GLI1. Breast cancer cells interact with osteoblasts and cause an enhanced differentiation of pre-osteoblasts to osteoblasts that express increased levels of the osteoclastogenesis factors, RANKL and PTHrP. There is sustained expression of osteoclast-promoting factors, RANKL and PTHrP, even after the osteoblast differentiation ceases and apoptosis sets in. Moreover, tumor cells that are deficient in Hh signaling are compromised in their ability to induce osteoblast differentiation and consequently are inefficient in causing osteolysis. The stimulation of osteoblast differentiation sets the stage for osteoclast differentiation and overall promotes osteolysis. Thus, in the process of developing newer therapeutic strategies against breast cancer metastasis to bone it would worthwhile to keep in mind the role of the Hh pathway in osteoblast differentiation in an otherwise predominant osteolytic phenomenon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.