ArticlePloS one2012
Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Distinct odorant receptor response patterns to aliphatic odorants in freely behaving mice.Chemical senses · 2025Article
- A Preliminary Investigation of Interspecific Chemosensory Communication of Emotions: Can Humans (Animals : an open access journal from MDPI · 2021Article
- Olfactory Detection Thresholds for Primary Aliphatic Alcohols in Mice.Chemical senses · 2020Article
- From sterile labs to rich VR: Immersive multisensory context critical for odors to induce motivated cleaning behavior.Behavior research methods · 2020Article
- Encoding fear intensity in human sweat.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Role of ecology in shaping external nasal morphology in bats and implications for olfactory tracking.PloS one · 2020Article
- Olfactory sensitivity for mold-associated odorants in CD-1 mice and spider monkeys.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Poor human olfaction is a 19th-century myth.Science (New York, N.Y.) · 2017Review
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- Characterizing olfactory binary mixture interactions in Fischer 344 rats using behavioral reaction times.Chemical senses · 2015Article
- An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.Scientific reports · 2015Article
- Characterizing olfactory perceptual similarity using carbon chain discrimination in Fischer 344 rats.Chemical senses · 2014Article
- Olfactory sensitivity for six predator odorants in CD-1 mice, human subjects, and spider monkeys.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated. With all 14 odorants, the animals significantly discriminated concentrations as low as 0.03 ppm (parts per million) from the solvent, and with four odorants the best-scoring animals even detected concentrations as low as 3 ppt (parts per trillion). Analysis of odor structure-activity relationships showed that the correlation between olfactory detection thresholds of the mice for the unbranched carboxylic acids and carbon chain length can best be described as a U-shaped function with the lowest threshold values at n-butanoic acid. A significant positive correlation between olfactory detection thresholds and carbon chain length of the carboxylic acids with their branching next to the functional carboxyl group was found. In contrast, no such correlation was found for carboxylic acids with their branching at the distal end of the carbon chain relative to the functional carboxyl group. Finally, a significant correlation was found between olfactory detection thresholds and the position of the branching of the carboxylic acids. Across-species comparisons suggest that mice are more sensitive for short-chained (C(2) to C(4)) aliphatic n-carboxylic acids than other mammalian species, but not for longer-chained ones (C(5) to C(8)). Further comparisons suggest that odor structure-activity relationships are both substance class- and species-specific.
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