ArticlePloS one2012
A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
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- Conditional Degradation of UNC-31/CAPS Enables Spatiotemporal Analysis of Neuropeptide Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.PLoS genetics · 2022Article
- Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism.PLoS biology · 2022Article
- Transcription Factors That Control Behavior-Lessons FromFrontiers in neuroscience · 2021Review
- Development of specialized sensory neurons engages a nuclear receptor required for functional plasticity.Genes & development · 2020Article
- Behavioral States.Genetics · 2020Review
- Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes.Nucleic acids research · 2020Article
- The role of carbon dioxide in nematode behaviour and physiology.Parasitology · 2020Review
- A single amino acid change in the EGL-46 transcription factor causes defects in BAG neuron specification.microPublication biology · 2020Article
- Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development inDevelopment (Cambridge, England) · 2019Article
- Lineage context switches the function of aDevelopment (Cambridge, England) · 2019Article
- Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing inBio-protocol · 2018Article
- A Single Set of Interneurons Drives Opposite Behaviors in C. elegans.Current biology : CB · 2017Article
- The ETS-5 transcription factor regulates activity states inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.Scientific reports · 2017Article
- Mechanisms of host seeking by parasitic nematodes.Molecular and biochemical parasitology · 2016Review
- A map of terminal regulators of neuronal identity in Caenorhabditis elegans.Wiley interdisciplinary reviews. Developmental biology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.