ArticlePloS one2012
The transcriptome and proteome of the diatom Thalassiosira pseudonana reveal a diverse phosphorus stress response.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed, 326 citations in OpenAlex.
- Non-Classical Spring-to-Summer Phytoplankton Community Reorganization in Liaodong Bay Associated with Shifts in Phosphorus Regime and Nutrient Stoichiometry.Microorganisms · 2026Article
- A plasma membrane Ca2+-dependent protein kinase PtCDPK2 promotes phosphorus starvation resilience in Phaeodactylum tricornutum.Journal of experimental botany · 2026Article
- Phosphorus Acquisition Strategies Among Phytoplankton and Free-Living Bacterial Communities in the Baltic Proper.Environmental microbiology reports · 2026Article
- Phosphorus acquisition among planktonic microbial communities across a salinity gradient.ISME communications · 2026Article
- Dealing with phosphorus deficiency: contrasting strategies in marine phytoplankton and bacteria.ISME communications · 2026Article
- Polyphosphate Polymerase-A Key Enzyme for the Phosphorus Economy of the Microalgal Cell and the Sustainable Usage of This Nutrient.Plants (Basel, Switzerland) · 2025Review
- Nitrogen status exerts dynamic control over phosphorus sensing and acquisition via PSR1 in colimited marine diatoms.Science advances · 2025Article
- Nitrogen and phosphorus differentially control marine biomass production and stoichiometry.Nature communications · 2025Article
- Transcriptomic response of marine dinoflagellate Prorocentrum cordatum to phosphorus deficiency.Scientific reports · 2025Article
- Distinctive physiology of polyphosphate-accumulatingApplied and environmental microbiology · 2025Article
- Microeukaryote metabolism across the western North Atlantic Ocean revealed through autonomous underwater profiling.Nature communications · 2024Article
- Phosphorous Utilization in Microalgae: Physiological Aspects and Applied Implications.Plants (Basel, Switzerland) · 2024Review
- First regional reference database of northern Adriatic diatom transcriptomes.Scientific reports · 2024Article
- Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient.Plants (Basel, Switzerland) · 2024Review
- Biogenic Phosphonate Utilization by Globally Distributed DiatomMicroorganisms · 2024Article
- Review
- Phosphate Limitation Responses in Marine Green Algae Are Linked to Reprogramming of the tRNA Epitranscriptome and Codon Usage Bias.Molecular biology and evolution · 2023Article
- Efficient modulation of cellular phosphorus components in response to phosphorus deficiency in the dinoflagellateApplied and environmental microbiology · 2023Article
- Two-sided effects of the organic phosphorus phytate on a globally important marine coccolithophorid phytoplankton.Microbiology spectrum · 2023Article
- Transcriptomic Analysis of the Response of the Toxic DinoflagellateMicroorganisms · 2023Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus (P) is a critical driver of phytoplankton growth and ecosystem function in the ocean. Diatoms are an abundant class of marine phytoplankton that are responsible for significant amounts of primary production. With the control they exert on the oceanic carbon cycle, there have been a number of studies focused on how diatoms respond to limiting macro and micronutrients such as iron and nitrogen. However, diatom physiological responses to P deficiency are poorly understood. Here, we couple deep sequencing of transcript tags and quantitative proteomics to analyze the diatom Thalassiosira pseudonana grown under P-replete and P-deficient conditions. A total of 318 transcripts were differentially regulated with a false discovery rate of <0.05, and a total of 136 proteins were differentially abundant (p<0.05). Significant changes in the abundance of transcripts and proteins were observed and coordinated for multiple biochemical pathways, including glycolysis and translation. Patterns in transcript and protein abundance were also linked to physiological changes in cellular P distributions, and enzyme activities. These data demonstrate that diatom P deficiency results in changes in cellular P allocation through polyphosphate production, increased P transport, a switch to utilization of dissolved organic P through increased production of metalloenzymes, and a remodeling of the cell surface through production of sulfolipids. Together, these findings reveal that T. pseudonana has evolved a sophisticated response to P deficiency involving multiple biochemical strategies that are likely critical to its ability to respond to variations in environmental P availability.
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