ArticlePloS one2012
Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis.Advanced healthcare materials · 2025Article
- Proteomic Analysis of Chicken Chorioallantoic Membrane (CAM) during Embryonic Development Provides Functional Insight.BioMed research international · 2022Article
- Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells.International journal of molecular sciences · 2021Review
- Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1.iScience · 2021Article
- In Situ DNA/Protein Interaction Assay to Visualize Transcriptional Factor Activation.Methods and protocols · 2020Article
- Toward the Optimization of Click-Mediated Pretargeted Radioimmunotherapy.Molecular pharmaceutics · 2019Article
- An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse.Journal of visualized experiments : JoVE · 2018Article
- Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis.Nature communications · 2018Article
- From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.Angewandte Chemie (International ed. in English) · 2017Review
- In vivo histone H1 migration from necrotic to viable tissue.Oncotarget · 2017Article
- Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer.Cancer research · 2016Article
- High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.Scientific reports · 2015Article
- Egg-in-cube: design and fabrication of a novel artificial eggshell with functionalized surface.PloS one · 2015Article
- Techniques and assays for the study of angiogenesis.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- The chicken chorioallantoic membrane model in biology, medicine and bioengineering.Angiogenesis · 2014Review
- The chick embryo as an expanding experimental model for cancer and cardiovascular research.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging.Cell adhesion & migration · 2014Article
- Controlling matrix stiffness and topography for the study of tumor cell migration.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The leaky, heterogeneous vasculature of human tumors prevents the even distribution of systemic drugs within cancer tissues. However, techniques for studying vascular delivery systems in vivo often require complex mammalian models and time-consuming, surgical protocols. The developing chicken embryo is a well-established model for human cancer that is easily accessible for tumor imaging. To assess this model for the in vivo analysis of tumor permeability, human tumors were grown on the chorioallantoic membrane (CAM), a thin vascular membrane which overlays the growing chick embryo. The real-time movement of small fluorescent dextrans through the tumor vasculature and surrounding tissues were used to measure vascular leak within tumor xenografts. Dextran extravasation within tumor sites was selectively enhanced an interleukin-2 (IL-2) peptide fragment or vascular endothelial growth factor (VEGF). VEGF treatment increased vascular leak in the tumor core relative to surrounding normal tissue and increased doxorubicin uptake in human tumor xenografts. This new system easily visualizes vascular permeability changes in vivo and suggests that vascular permeability may be manipulated to improve chemotherapeutic targeting to tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.