ArticlePloS one2012
Genome-wide association study of treatment refractory schizophrenia in Han Chinese.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.BMC psychiatry · 2017Pooled it
- Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysis.Genomics, proteomics & bioinformatics · 2014Pooled it
- Pooled it
- Shared and unique therapeutic targets of KarXT and clozapine for schizophrenia treatment revealed by network pharmacology and molecular docking analyses: Implications for differential clinical responses.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Article
- Association between rs1344706 Polymorphism in the ZNF804A Gene and the Risk for Schizophrenia.Iranian journal of psychiatry · 2021Article
- Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.International journal of molecular sciences · 2021Article
- Comprehensive Analysis of RNA-Seq Gene Expression Profiling of Brain Transcriptomes Reveals Novel Genes, Regulators, and Pathways in Autism Spectrum Disorder.Brain sciences · 2020Article
- Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks.Molecular psychiatry · 2020Article
- Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates.Frontiers in pharmacology · 2019Review
- The Potential Role of Regulatory Genes (Frontiers in genetics · 2019Article
- The NF-κB signaling pathway: an important therapeutic target in psychiatric disorders.Molecular psychiatry · 2018Article
- Progress in genome-wide association studies of schizophrenia in Han Chinese populations.NPJ schizophrenia · 2017Review
- The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.Molecular psychiatry · 2017Review
- Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations.Scientific reports · 2017Article
- A novel relationship for schizophrenia, bipolar and major depressive disorder Part 5: a hint from chromosome 5 high density association screen.American journal of translational research · 2017Article
- Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach.Neuropsychiatric disease and treatment · 2017Article
- Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project.Human molecular genetics · 2016Article
- The dopamine beta-hydroxylase gene polymorphism rs1611114 is associated with schizophrenia in the Chinese Zhuang but not Chinese Han population.Molecular genetics and genomics : MGG · 2016Article
- Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.Schizophrenia research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04 × 10(-7)) and rs11265461 (P = 1.94 × 10(-7)) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94 × 10(-6)) and rs230529 (P = 1.74 × 10(-7)) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05 × 10(-5)) and rs3827219 (P = 1.66 × 10(-5)) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87 × 10(-5)) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85 × 10(-6)). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS.
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Registered trials
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