ArticlePloS one2012
Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Ultrasensitive detection and quantification of bovine Deltapapillomavirus in the semen of healthy horses.Scientific reports · 2025Article
- Molecular findings and virological assessment of bladder papillomavirus infection in cattle.The veterinary quarterly · 2024Article
- Exploring the therapeutic potential ofVeterinary world · 2024Article
- Bovine papillomavirus vertical transmission: BPV diversity and expression in maternal and fetal tissues.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Vertical Intrauterine Bovine and Ovine Papillomavirus Coinfection in Pregnant Cows.Pathogens (Basel, Switzerland) · 2024Article
- Genetic Evaluation of Bovine Papillomavirus Types Associated with Teat Papillomatosis in Polish Dairy Cattle with the Report of a New Putative Type.Pathogens (Basel, Switzerland) · 2023Article
- Bovine Papillomavirus Type 1 Infection in an Equine Congenital Papilloma.Pathogens (Basel, Switzerland) · 2023Article
- Congenital Oral Squamous Cell Carcinoma in a Suckling Piglet.Case reports in veterinary medicine · 2021Article
- Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily.Pathogens (Basel, Switzerland) · 2020Article
- Bovine Papillomavirus Type 2 Infection Associated with Papillomatosis of the Amniotic Membrane in Water Buffaloes (Pathogens (Basel, Switzerland) · 2020Article
- The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs.Viruses · 2020Article
- Molecular Detection of Bovine Papillomavirus DNA in the Placenta and Blood of Healthy Mares and Respective Foals.Veterinary sciences · 2019Article
- Detection of bovine papillomavirus type 2 DNA in calf conjunctival myofibroblastoma.The Journal of veterinary medical science · 2018Article
- Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus.Scientific reports · 2018Article
- Detection and phylogenetic analysis of bovine papillomavirus in cutaneous warts in cattle in Tamaulipas, Mexico.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2016Article
- Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle.Advances in virology · 2016Article
- Intranuclear Inclusions in Renal Tubular Epithelium in Immunodeficient Mice Stain with Antibodies for Bovine Papillomavirus Type 1 L1 Protein.Veterinary sciences · 2015Article
- Article
- The E5 proteins.Virology · 2013Review
- Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?Infectious agents and cancer · 2013Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillomaviruses (PVs) are believed to be highly epitheliotropic as they usually establish productive infections within stratified epithelia. In vitro, various PVs appear to complete their entire life-cycle in different trophoblastic cell lines. In this study, infection by and protein expression of bovine papillomavirus type 2 (BPV-2) in the uterine and chorionic epithelium of the placenta has been described in four cows suffering from naturally occurring papillomavirus-associated urothelial bladder tumors. E5 oncoprotein was detected both by Western blot analysis and immunohistochemically. It appears to be complexed and perfectly co-localized with the activated platelet-derived growth factor ß receptor (PDGFßR) by laser scanning confocal microscopy. The activated PDGFßR might be involved in organogenesis and neo-angiogenesis rather than in cell transformation during pregnancy. The major capsid protein, L1, believed to be only expressed in productive papillomavirus infection has been detected by Western blot analysis. Immunohistochemical investigations confirmed the presence of L1 protein both in the cytoplasm and nuclei of cells of the uterine and chorionic epithelium. Trophoblastic cells appear to be the major target for L1 protein expression. Finally, the early protein E2, required for viral DNA replication and known to be expressed during a productive infection, has been detected by Western blot and immunohistochemically. Electron microscopic investigations detected viral particles in nuclei of uterine and chorionic epithelium. This study shows that both active and productive infections by BPV-2 in the placenta of pregnant cows can occur in vivo.
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