ArticlePloS one2012
Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Chronic Manganese Neuro-Toxicity in a Patient With Cirrhosis and the Role of Iron-Deficiency Anaemia.Cureus · 2024Article
- Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice.Archives of toxicology · 2021Article
- In-feed organic and inorganic manganese supplementation on broiler performance and physiological responses.Animal bioscience · 2021Article
- Uptake of Manganese from the Manganese-Lysine Complex in Primary Chicken Intestinal Epithelial Cells.Animals : an open access journal from MDPI · 2019Article
- Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves.Journal of toxicology and environmental health. Part A · 2019Article
- Manganese transport and toxicity in polarized WIF-B hepatocytes.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity.Neurotoxicology · 2018Article
- Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice.Neurotoxicology · 2018Article
- Influence of iron metabolism on manganese transport and toxicity.Metallomics : integrated biometal science · 2017Review
- Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure.Metallomics : integrated biometal science · 2016Article
- Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity.Scientific reports · 2016Article
- Mechanisms of divalent metal toxicity in affective disorders.Toxicology · 2016Review
- Pica for Uncooked Basmati Rice in Two Women with Iron Deficiency and a Review of Ryzophagia.Case reports in medicine · 2016Article
- Effect of Hfe Deficiency on Memory Capacity and Motor Coordination after Manganese Exposure by Drinking Water in Mice.Toxicological research · 2015Article
- Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis.Environmental toxicology and pharmacology · 2015Article
- Loss of hfe function reverses impaired recognition memory caused by olfactory manganese exposure in mice.Toxicological research · 2015Article
- Article
- Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water.Archives of toxicology · 2014Article
- Pathophysiology of the Belgrade rat.Frontiers in pharmacology · 2014Review
- Intranasal administration of oxytocin: behavioral and clinical effects, a review.Neuroscience and biobehavioral reviews · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Iron-responsive manganese uptake is increased in iron-deficient rats, suggesting that toxicity related to manganese exposure could be modified by iron status. To explore possible interactions, the distribution of intranasally-instilled manganese in control and iron-deficient rat brain was characterized by quantitative image analysis using T1-weighted magnetic resonance imaging (MRI). Manganese accumulation in the brain of iron-deficient rats was doubled after intranasal administration of MnCl(2) for 1- or 3-week. Enhanced manganese level was observed in specific brain regions of iron-deficient rats, including the striatum, hippocampus, and prefrontal cortex. Iron-deficient rats spent reduced time on a standard accelerating rotarod bar before falling and with lower peak speed compared to controls; unexpectedly, these measures of motor function significantly improved in iron-deficient rats intranasally-instilled with MnCl(2). Although tissue dopamine concentrations were similar in the striatum, dopamine transporter (DAT) and dopamine receptor D(1) (D1R) levels were reduced and dopamine receptor D(2) (D2R) levels were increased in manganese-instilled rats, suggesting that manganese-induced changes in post-synaptic dopaminergic signaling contribute to the compensatory effect. Enhanced olfactory manganese uptake during iron deficiency appears to be a programmed "rescue response" with beneficial influence on motor impairment due to low iron status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.