ArticlePloS one2012
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.Signal transduction and targeted therapy · 2026Article
- Targeting HDACs with dacinostat amplifies radiation-induced DNA damage via sustained phosphorylated p53 and repair inhibition in aggressive meningioma.Cell death & disease · 2026Article
- Exploring the Regulation ofJournal of developmental biology · 2025Article
- Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters.Nucleic acids research · 2021Article
- Haloperidol Metabolite II Valproate Ester (Journal of medicinal chemistry · 2021Article
- Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition.Nucleic acids research · 2021Article
- Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.Scientific reports · 2021Article
- Valproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways.Scientific reports · 2021Article
- The Effect of Sodium Butyrate on Adventitious Shoot Formation Varies among the Plant Species and the Explant Types.International journal of molecular sciences · 2020Article
- Mechanism of Action for HDAC Inhibitors-Insights from Omics Approaches.International journal of molecular sciences · 2019Review
- Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation.Epigenetics · 2018Article
- Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells.Frontiers in immunology · 2017Article
- Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation ofClinical epigenetics · 2017Article
- Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Histone deacetylase inhibitors as cancer therapeutics.Annals of translational medicine · 2016Article
- Epigenetic origin of adaptive phenotypic variants in the human blood fluke Schistosoma mansoni.Epigenetics & chromatin · 2016Article
- MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis.BBA clinical · 2015Article
- Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy.Genes & cancer · 2015Review
- Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response.Epigenetics & chromatin · 2015Article
- HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes.Epigenetics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60 cells with different HDACi (valproic acid, Trichostatin A, suberoylanilide hydroxamic acid). Different gene populations respond to each inhibitor, with as many genes down- as up-regulated. Surprisingly, HDACi rarely induced increased histone acetylation at gene promoters, with most genes examined showing minimal change, irrespective of whether genes were up- or down-regulated. Many genes seem to be sheltered from the global histone hyperacetyation induced by HDACi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.