ArticlePloS one2012
The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.Human molecular genetics · 2013Pooled it
- A 'Standard of Care PLUS' Model for Preterm Birth Prevention: Integrating Nutrient and Gene Variant Analysis with Targeted Interventions.Journal of personalized medicine · 2026Article
- Genetic contributions to pain modulation in sickle cell: A focus on single nucleotide polymorphisms.Gene reports · 2024Article
- Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus.Frontiers in endocrinology · 2020Review
- Heterogeneous impact of type 2 diabetes mellitus-related genetic variants on gestational glycemic traits: review and future research needs.Molecular genetics and genomics : MGG · 2019Review
- Adiponectin gene polymorphisms and risk of gestational diabetes mellitus: A meta-analysis.World journal of clinical cases · 2019Article
- Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis.World journal of clinical cases · 2019Article
- Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview.Journal of diabetes research · 2019Review
- Effects of maternal and fetal LEP common variants on maternal glycemic traits in pregnancy.Scientific reports · 2017Article
- CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study.Scientific reports · 2017Article
- Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy.Scientific reports · 2017Article
- Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.Current diabetes reports · 2016Review
- Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women.PloS one · 2015Article
- Intersection of complex genetic traits affecting maternal metabolism, fetal metabolism, and neural tube defect risk: looking for needles in multiple haystacks.Molecular genetics and metabolism · 2014Article
- Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy.Diabetic medicine : a journal of the British Diabetic Association · 2014Review
- Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.Annals of human genetics · 2013Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSince mediators of inflammation are associated with insulin resistance, and the risk of developing diabetes mellitus and gestational diabetes, we hypothesized that genetic variation in members of the inflammatory gene pathway impact glucose levels and related phenotypes in pregnancy. We evaluated this hypothesis by testing for association between genetic variants in 31 inflammatory pathway genes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort, a large multiethnic multicenter study designed to address the impact of glycemia less than overt diabetes on pregnancy outcome.
resultsFasting, 1-hour, and 2-hour glucose, fasting and 1-hour C-peptide, and HbA1c levels were measured in blood samples obtained from HAPO participants during an oral glucose tolerance test at 24-32 weeks gestation. We tested for association between 458 SNPs mapping to 31 genes in the inflammatory pathway and metabolic phenotypes in 3836 European ancestry and 1713 Thai pregnant women. The strongest evidence for association was observed with TNF alpha and HbA1c (rs1052248; 0.04% increase per allele C; p-value = 4.4×10(-5)), RETN and fasting plasma glucose (rs1423096; 0.7 mg/dl decrease per allele A; p-value = 1.1×10(-4)), IL8 and 1 hr plasma glucose (rs2886920; 2.6 mg/dl decrease per allele T; p-value = 1.3×10(-4)), ADIPOR2 and fasting C-peptide (rs2041139; 0.55 ug/L decrease per allele A; p-value = 1.4×10(-4)), LEPR and 1-hour C-peptide (rs1171278; 0.62 ug/L decrease per allele T; p-value = 2.4×10(-4)), and IL6 and 1-hour plasma glucose (rs6954897; -2.29 mg/dl decrease per allele G, p-value = 4.3×10(-4)).
conclusionsBased on the genes surveyed in this study the inflammatory pathway is unlikely to have a strong impact on maternal metabolic phenotypes in pregnancy although variation in individual members of the pathway (e.g. RETN, IL8, ADIPOR2, LEPR, IL6, and TNF alpha,) may contribute to metabolic phenotypes in pregnant women.
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