Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
Vesna Boraska, Aaron Day-Williams, Christopher S Franklin, Katherine S Elliott, Kalliope Panoutsopoulou, Ioanna Tachmazidou, Eva Albrecht, Stefania Bandinelli, Lawrence J Beilin, Murielle Bochud and 56 more
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
66 authors.
Vesna BoraskaWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom. vb2@sanger.ac.uk
Aaron Day-Williams
Christopher S Franklin
Katherine S Elliott
Kalliope Panoutsopoulou
Ioanna Tachmazidou
Eva Albrecht
Stefania Bandinelli
Lawrence J Beilin
Murielle Bochud
Gemma Cadby
Florian Ernst
David M Evans
Caroline Hayward
Andrew A Hicks
Jennifer Huffman
Cornelia Huth
Alan L James
Norman Klopp
Ivana Kolcic
Zoltán Kutalik
Debbie A Lawlor
Arthur W Musk
Marina Pehlic
Craig E Pennell
John R B Perry
Annette Peters
Ozren Polasek
Beate St Pourcain
Susan M Ring
Erika Salvi
Sabine Schipf
Jan A Staessen
Alexander Teumer
Nicholas Timpson
Veronique Vitart
Nicole M Warrington
Hanieh Yaghootkar
Tatijana Zemunik
Lina Zgaga
Ping An
Verneri Anttila
Ingrid B Borecki
Jostein Holmen
Ioanna Ntalla
Aarno Palotie
Kirsi H Pietiläinen
Juho Wedenoja
Bendik S Winsvold
George V Dedoussis
Jaakko Kaprio
Michael A Province
John-Anker Zwart
Michel Burnier
Harry Campbell
Daniele Cusi
George Davey Smith
Timothy M Frayling
Christian Gieger
Lyle J Palmer
Peter P Pramstaller
Igor Rudan
Henry Völzke
H-Erich Wichmann
Alan F Wright
Eleftheria Zeggini
Funding
FHS-SCAN Genome Wide Association Scan for Atherosclerosis Pathway GenesR01HL087700 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2006 to 2008
$5.4M
Genetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6M
GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCANR01HL088215 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2008 to 2011
$3.0M
Genetic Epidemiology of Metabolic Diseases of ObesityR01DK075681 · NIDDK · WASHINGTON UNIVERSITY · PI BORECKI, INGRID BERNADETTE · 2008 to 2011
$2.1M
HISPANIC SECONDARY STROKE PREVENTION INITIATIVER01MD009164 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN · 2014 to 2018
$1.9M
THE INCHIANTI FOLLOW-UP STUDY-260012111N01AG012111 · NIA · ITALIAN NATL. INST. ON AGING · 2003 to 2003
–
CIHR MOP-82893Intramural NIH HHSMedical Research Council G0600705Medical Research Council G0800582Medical Research Council G9815508Medical Research Council MC_PC_U127561128Medical Research Council MC_U127561128NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01-HL-087700NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01-HL-088215NIA NIH HHS N01-AG-5-0002NIA NIH HHS N1-AG-1-1NIA NIH HHS N1-AG-1-2111NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01-DK-075681NIDDK NIH HHS R01-DK-8925601NIMHD NIH HHS 263 MD 821336NIMHD NIH HHS 263 MD 9164NIMHD NIH HHS R01 MD009164Wellcome Trust 092731Wellcome Trust 098051Wellcome Trust WT089062
6 · The paper itself
Abstract
Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.
Indexed as
Polymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnthropometryArmBody Mass IndexChromosome MappingCohort StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanProteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. · full record | OpenQuestion